Evidence map›Paper›PMID 35482161›Full record

ReviewWorld journal of microbiology & biotechnology2022

Debaryomyces hansenii: an old acquaintance for a fresh start in the era of the green biotechnology.

Clara Navarrete, Mònica Estrada, José L Martínez

Abstract readReview
In one paragraph

Review in World journal of microbiology & biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Mechanisms of the marine yeastApplied and environmental microbiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Clara NavarreteDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads Building 223, 2800, Kgs. Lyngby, Denmark.
Mònica EstradaDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads Building 223, 2800, Kgs. Lyngby, Denmark.
José L MartínezSection of Synthetic Biology (DTU Bioengineering), Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads Building 223, 2800, Kgs. Lyngby, Denmark. jlmr@dtu.dk.ORCID http://orcid.org/0000-0002-4490-8534

Funding

European Cooperation in Science and Technology CA-18229Novo Nordisk Fonden NNF17SA0031362Novo Nordisk Fonden NNF19SA0057794
6 · The paper itself

Abstract

The halophilic yeast Debaryomyces hansenii has been studied for several decades, serving as eukaryotic model for understanding salt and osmotic tolerance. Nevertheless, lack of consensus among different studies is found and, sometimes, contradictory information derived from studies performed in very diverse conditions. These two factors hampered its establishment as the key biotechnological player that was called to be in the past decade. On top of that, very limited (often deficient) engineering tools are available for this yeast. Fortunately Debaryomyces is again gaining momentum and recent advances using highly instrumented lab scale bioreactors, together with advanced -omics and HT-robotics, have revealed a new set of interesting results. Those forecast a very promising future for D. hansenii in the era of the so-called green biotechnology. Moreover, novel genetic tools enabling precise gene editing on this yeast are now available. In this review, we highlight the most recent developments, which include the identification of a novel gene implicated in salt tolerance, a newly proposed survival mechanism for D. hansenii at very high salt and limiting nutrient concentrations, and its utilization as production host in biotechnological processes.

Indexed as

DebaryomycesSaccharomycetalesBiotechnologyFriendsHumansSaccharomyces cerevisiaeFermentationGreen transitionNon-conventional yeastOmics technologiesSalt toleranceWaste revalorization

Identifiers

PMID35482161
PMCPMC9050785

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.