Evidence map›Paper›PMID 35482151›Full record

ArticleInsights into imaging2022

Differentiation of hepatocellular adenoma by subtype and hepatocellular carcinoma in non-cirrhotic liver by fractal analysis of perfusion MRI.

Florian Michallek, Riccardo Sartoris, Aurélie Beaufrère, Marco Dioguardi Burgio, François Cauchy, Roberto Cannella, Valérie Paradis, Maxime Ronot, Marc Dewey, Valérie Vilgrain

Open access · goldAbstract read
In one paragraph

Article in Insights into imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 5 countries.

Florian MichallekDepartment of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany. florian.michallek@charite.de.ORCID http://orcid.org/0000-0002-5475-0873
Riccardo SartorisUniversité de Paris, CRI, U1149, Paris, France.
Aurélie BeaufrèreUniversité de Paris, CRI, U1149, Paris, France.
Marco Dioguardi BurgioUniversité de Paris, CRI, U1149, Paris, France.
François CauchyDepartment of HBP Surgery, Hôpital Beaujon, AP-HP.Nord, 100 Boulevard du Général Leclerc, 92110, Clichy, France.
Roberto CannellaDepartment of Radiology, Hôpital Beaujon, AP-HP.Nord, 100 Boulevard du Général Leclerc, 92110, Clichy, France.
Valérie ParadisDepartment of Pathology, Hôpital Beaujon, AP-HP.Nord, 100 Boulevard du Général Leclerc, 92110, Clichy, France.
Maxime RonotUniversité de Paris, CRI, U1149, Paris, France.
Marc Dewey *Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Valérie Vilgrain *Université de Paris, CRI, U1149, Paris, France.
Université Paris Cité · FRHôpital Beaujon · FRGerman Cancer Research Center · DEHumboldt-Universität zu Berlin · DE

Funding

Berlin Institute of Health Digital Health Accelerator
6 · The paper itself

Abstract

backgroundTo investigate whether fractal analysis of perfusion differentiates hepatocellular adenoma (HCA) subtypes and hepatocellular carcinoma (HCC) in non-cirrhotic liver by quantifying perfusion chaos using four-dimensional dynamic contrast-enhanced magnetic resonance imaging (4D-DCE-MRI).

resultsA retrospective population of 63 patients (47 female) with histopathologically characterized HCA and HCC in non-cirrhotic livers was investigated. Our population consisted of 13 hepatocyte nuclear factor (HNF)-1α-inactivated (H-HCAs), 7 β-catenin-exon-3-mutated (b

conclusionsCombining qualitative MRI features with fractal analysis allows identification of HCA subtypes and HCCs in patients with non-cirrhotic livers and improves differentiation of lesions with high and low risk for malignant transformation.

Indexed as

FractalsHepatocellular adenomaHepatocellular carcinomaMagnetic resonance imagingPerfusion

Identifiers

PMID35482151
PMCPMC9050986
OpenAlexW4225001743

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.