Evidence map›Paper›PMID 35482084›Full record

ArticleClinical oral investigations2022

The association between the severity of periodontitis and osteonecrosis of the jaw in patients with different cancer locations: a nationwide population-based study.

Yi-Fang Huang, Kuan-Chou Lin, Shih-Ping Liu, Chung-Ta Chang, Chih-Hsin Muo, Po-Jen Chang, Chun-Hao Tsai, Ching-Zong Wu

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Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Yi-Fang HuangDepartment of General Dentistry, Chang Gung Memorial Hospital, Linkou, 33305, Taiwan.
Kuan-Chou LinSchool of Dentistry, College of Oral Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Xinyi Dist, Taipei, 11031, Taiwan.
Shih-Ping LiuGraduate Institute of Basic Medical Science, China Medical University, Taichung, 40402, Taiwan.
Chung-Ta ChangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Xinyi Dist, Taipei, 11031, Taiwan.
Chih-Hsin MuoManagement Office for Health Data, China Medical University Hospital, Taichung, 40402, Taiwan.
Po-Jen ChangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Xinyi Dist, Taipei, 11031, Taiwan.
Chun-Hao TsaiGraduate Institute of Clinical Medicine, China Medical University, Taichung, 40402, Taiwan.
Ching-Zong WuSchool of Dentistry, College of Oral Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Xinyi Dist, Taipei, 11031, Taiwan. chinaowu@tmu.edu.tw.ORCID http://orcid.org/0000-0001-8152-791X
China Medical University · TWAsia University · TWChang Gung University · TWFar Eastern Memorial Hospital · TWLuodong Poh-Ai Hospital · TWTaipei Medical University · TWWan Fang Hospital · TW

Funding

Chang Gung Memorial Hospital, Linkou CMRPG3L0051China Medical University Hospital DMR-109-126Far Eastern Memorial Hospital FEMH-2021-C-051Ministry of Health and Welfare MOHW109-TDU-B-212-114004Ministry of Science and Technology, Taiwan MOST 109-2321-B-039-002
6 · The paper itself

Abstract

objectivesTo determine the relation between the severity of periodontitis and osteonecrosis of the jaw (ONJ) occurrence among different cancer locations and estimate the effect of dental care on ONJ prevention in cancer patients. MATERIALS AND

methodsThis population-based cross-sectional study was conducted through the Longitudinal Health Insurance Database, Taiwan. Patients with malignancies were collected and subdivided into groups according to their different cancer locations, the severity of periodontitis, and dental care. Multivariable logistic regression analysis was performed to assess the associations between ONJ and ONJ-related factors.

resultsA total of 8,234 ONJ patients and 32,912 control patients were investigated. Lip, oral cavity, and pharynx malignancies had the highest ONJ risk among all cancer locations (OR from 3.07 to 9.56, P < 0.01). There is a linear relationship between different severities of periodontitis and ONJ. Patients with radiotherapy and severe periodontitis had the highest ONJ risk (adjusted OR, 9.56; 95% CI, 5.34-17.1). Patients with good dental care had a lower ONJ risk.

conclusionsThe periodontal condition and cancer location showed a significant impact on the risk of developing ONJ after adjusting for bisphosphonate use. Good dental care could decrease the risk of ONJ in cancer patients. The severity of periodontitis might be a target to predict the potency of ONJ. CLINICAL RELEVANCE: Dentists must be vigilant about the increased risk of ONJ in cancer patients with periodontitis, especially in the head and neck cancer population. Good dental care is advised for cancer patients with severe periodontitis.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsHead and Neck NeoplasmsOsteonecrosisPeriodontitisCross-Sectional StudiesDiphosphonatesHumansRisk FactorsBone Density Conservation AgentsDiphosphonatesCancer locationDental careONJOsteonecrosis of the jawPeriodontitisPopulation-based

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PMID35482084
OpenAlexW4225105856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.