Evidence map›Paper›PMID 35482068›Full record

Observational studyArchives of gynecology and obstetrics2023

Long-term effects of preeclampsia on maternal cardiovascular health and postpartum utilization of primary care: an observational claims data study.

Kathrin Haßdenteufel, Mitho Müller, Raphael Gutsfeld, Maren Goetz, Armin Bauer, Markus Wallwiener, Sara Y Brucker, Stefanie Joos, Miriam Giovanna Colombo, Sabine Hawighorst-Knapstein and 4 more

Abstract readObservational Study
In one paragraph

Observational study in Archives of gynecology and obstetrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  5. Review
  6. Review
  7. Extracellular vesicles in preeclampsia: drivers of vascular dysfunction and inflammation.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  8. Article
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  10. Article
  11. Article
  12. Article
  13. Review
  14. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kathrin HaßdenteufelDepartment of Obstetrics and Gynecology, Heidelberg University, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany. Kathrin.hassdenteufel@med.uni-heidelberg.de.ORCID 0000-0003-0141-7425
Mitho MüllerDepartment of Psychology, Ludwig Maximilian University, Munich, Germany.
Raphael GutsfeldDepartment of Psychology, Ludwig Maximilian University, Munich, Germany.
Maren GoetzDepartment of General Pediatrics, University Children's Hospital, Heidelberg, Germany.
Armin BauerDepartment of Women's Health, University Hospital Tuebingen, Tuebingen, Germany.
Markus WallwienerDepartment of Obstetrics and Gynecology, Heidelberg University, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
Sara Y BruckerDepartment of Women's Health, University Hospital Tuebingen, Tuebingen, Germany.
Stefanie JoosInstitute for General Practice and Interprofessional Healthcare, Eberhardt-Karls-University, Tuebingen, Germany.
Miriam Giovanna ColomboInstitute for General Practice and Interprofessional Healthcare, Eberhardt-Karls-University, Tuebingen, Germany.
Sabine Hawighorst-KnapsteinDepartment of Health Promotion, AOK Baden-Wuerttemberg, Stuttgart, Germany.
Ariane ChaudhuriDepartment of Health Promotion, AOK Baden-Wuerttemberg, Stuttgart, Germany.
Gudula KirtschigDepartment of Health Promotion, AOK Baden-Wuerttemberg, Stuttgart, Germany.
Frauke SaalmannDepartment of Health Promotion, AOK Baden-Wuerttemberg, Stuttgart, Germany.
Stephanie WallwienerDepartment of Obstetrics and Gynecology, Heidelberg University, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePreeclampsia occurs in up to 15% of pregnancies and constitutes a major risk factor for cardiovascular disease. This observational cohort study aimed to examine the association between preeclamptic pregnancies and cardiovascular outcomes as well as primary and specialized care utilization after delivery.

methodsUsing statutory claims data we identified women with singleton live births between 2010 and 2017. Main outcomes included the occurrence of either hypertension or cardiovascular disease after one or more preeclamptic pregnancies, number of contacts to a general practitioner or cardiologist after delivery and prescribed antihypertensive medication. Data were analyzed using Cox proportional hazard regression models adjusted for maternal age, diabetes, dyslipidemia, and obesity.

resultsThe study cohort consisted of 181,574 women with 240,698 births. Women who experienced preeclampsia once had an increased risk for cardiovascular (hazard ratio, HR = 1.29) or hypertensive (HR = 4.13) events. In women affected by recurrent preeclampsia, risks were even higher to develop cardiovascular disease (HR = 1.53) or hypertension (HR = 6.01). In the following years after delivery, general practitioners were seen frequently, whereas cardiologists were consulted rarely (0.3 and 2.4%).

conclusionWomen affected by preeclampsia experience an increased risk of developing chronic hypertension and cardiovascular disease, especially those with recurrent preeclampsia. Future medical guidelines should take this potential risk into account.

Indexed as

Cardiovascular DiseasesHypertensionPre-EclampsiaFemaleHumansPostpartum PeriodPregnancyPrimary Health CareRisk FactorsCardiovascular diseaseHypertensionPreeclampsiaPregnancyPrimary care

Identifiers

PMID35482068
PMCPMC9836976

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.