Evidence map›Paper›PMID 35481854›Full record

ArticleBiofabrication2022

Engineering cryoelectrospun elastin-alginate scaffolds to serve as stromal extracellular matrices.

Pujhitha Ramesh, Nicholas Moskwa, Zachary Hanchon, Adam Koplas, Deirdre A Nelson, Kristen L Mills, James Castracane, Melinda Larsen, Susan T Sharfstein, Yubing Xie

Open access · greenAbstract read
In one paragraph

Article in Biofabrication, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Advances in Smart Responsive Nanofibers for Wound Healing.Biomimetics (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Salivary Gland Bioengineering.Bioengineering (Basel, Switzerland) · 2023
    Review
  8. Alginate microfibers as therapeutic delivery scaffolds and tissue mimics.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Pujhitha RameshCollege of Nanoscale Science and Engineering, SUNY Polytechnic Institute, 257 Fuller Road, Albany, NY 12203, United States of America.ORCID 0000-0002-0207-0366
Nicholas MoskwaDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave., Albany, NY 12222, United States of America.ORCID 0000-0002-9819-9227
Zachary HanchonCollege of Nanoscale Science and Engineering, SUNY Polytechnic Institute, 257 Fuller Road, Albany, NY 12203, United States of America.
Adam KoplasCollege of Nanoscale Science and Engineering, SUNY Polytechnic Institute, 257 Fuller Road, Albany, NY 12203, United States of America.
Deirdre A NelsonDepartment of Biological Sciences and The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave., Albany, NY 12222, United States of America.ORCID 0000-0001-5527-2570
Kristen L MillsDepartment of Mechanical, Aerospace, and Nuclear Engineering (MANE), Center for Biotechnology and Interdisciplinary Studies (CBIS), Rensselaer Polytechnic Institute, 1623 15th Street, Troy, NY 12180, United States of America.
James CastracaneCollege of Nanoscale Science and Engineering, SUNY Polytechnic Institute, 257 Fuller Road, Albany, NY 12203, United States of America.
Melinda LarsenCollege of Nanoscale Science and Engineering, SUNY Polytechnic Institute, 257 Fuller Road, Albany, NY 12203, United States of America.ORCID 0000-0002-5026-2012
Susan T SharfsteinCollege of Nanoscale Science and Engineering, SUNY Polytechnic Institute, 257 Fuller Road, Albany, NY 12203, United States of America.ORCID 0000-0002-0908-4197
Yubing XieCollege of Nanoscale Science and Engineering, SUNY Polytechnic Institute, 257 Fuller Road, Albany, NY 12203, United States of America.ORCID 0000-0003-1395-7365
SUNY Polytechnic Institute · USAlbany State University · USRensselaer Polytechnic Institute · US

Funding

Remediating fibrosis for salivary gland regenerationR01DE027953 · NIDCR · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI MELINDA LARSEN · 2019 to 2026
$5.4M
NIDCR NIH HHS R01 DE027953
6 · The paper itself

Abstract

Scaffold-based regenerative strategies that emulate physical, biochemical, and mechanical properties of the native extracellular matrix (ECM) of the region of interest can influence cell growth and function. Existing ECM-mimicking scaffolds, including nanofiber (NF) mats, sponges, hydrogels, and NF-hydrogel composites are unable to simultaneously mimic typical composition, topography, pore size, porosity, and viscoelastic properties of healthy soft-tissue ECM. In this work, we used cryoelectrospinning to fabricate 3D porous scaffolds with minimal fibrous backbone, pore size and mechanical properties similar to soft-tissue connective tissue ECM. We used salivary glands as our soft tissue model and found the decellularized adult salivary gland (DSG) matrix to have a fibrous backbone, 10-30

Indexed as

AlginatesElastinConnective TissueExtracellular MatrixHydrogelsSolventsTissue EngineeringTissue ScaffoldsWaterAlginatesElastinHydrogelsSolventsWater3D porous scaffoldalginatecryoelectrospinningelastinextracellular matrixsalivary glandsoft tissue engineering

Identifiers

PMID35481854
PMCPMC9973022
OpenAlexW4225080764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.