Evidence map›Paper›PMID 35481749›Full record

ArticlemBio2022

Generation of Mature DENVs via Genetic Modification and Directed Evolution.

Longping V Tse, Rita M Meganck, Stephanie Dong, Lily E Adams, Laura J White, Michael L Mallory, Ramesh Jadi, Aravinda M de Silva, Ralph S Baric

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Longping V TseDepartment of Epidemiology, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.ORCID 0000-0001-7582-8396
Rita M MeganckDepartment of Epidemiology, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Stephanie DongDepartment of Epidemiology, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Lily E AdamsDepartment of Epidemiology, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.ORCID 0000-0001-7780-9973
Laura J WhiteDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Michael L MalloryDepartment of Epidemiology, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Ramesh JadiDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Aravinda M de SilvaDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Ralph S BaricDepartment of Epidemiology, The University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.ORCID 0000-0001-6827-8701
University of North Carolina at Chapel Hill · US

Funding

T Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus VaccinationP01AI106695 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Aravinda M. DeSilva · 2015 to 2026
$34.1M
PRECLINICAL ASSAYS TO PREDICT TETRAVALENT DENGUE VACCINE EFFICACYR01AI125198 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DESILVA, ARAVINDA M. · 2016 to 2020
$5.7M
Molecular Basis of Flavivirus Cross-Neutralization by Human AntibodiesR01AI107731 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DESILVA, ARAVINDA M. · 2013 to 2022
$5.3M
NIAID NIH HHS P01 AI106695NIAID NIH HHS R01 AI107731NIAID NIH HHS R01 AI125198
6 · The paper itself

Abstract

Maturation of dengue viruses (DENVs) alters the structure, immunity, and infectivity of the virion and highly mature particles represent the dominant form

Indexed as

DengueDengue VirusAnimalsAntibodies, ViralFurinMammalsSerogroupViral Envelope ProteinsVirionAntibodies, ViralFurinViral Envelope Proteinsantigenicitydengue virusdirected evolutionmaturationviral engineering

Identifiers

PMID35481749
PMCPMC9239201
OpenAlexW4225087943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.