Evidence map›Paper›PMID 35481647›Full record

ArticleProtein science : a publication of the Protein Society2022

Relative domain orientation of the L289K HIV-1 reverse transcriptase monomer.

Zhaoyong Xi, Tatiana V Ilina, Michel Guerrero, Lixin Fan, Nicolas Sluis-Cremer, Yun-Xing Wang, Rieko Ishima

Open access · bronzeAbstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Small-angle X-ray scattering studies of enzymes.Current opinion in chemical biology · 2023
    Review
  2. Relative domain orientation of the L289K HIV-1 reverse transcriptase monomer.Protein science : a publication of the Protein Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zhaoyong XiDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Tatiana V IlinaDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-9985-5978
Michel GuerreroDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Lixin FanBasic Science Program, Frederick National Laboratory for Cancer Research, SAXS Core Facility of the National Cancer Institute, Frederick, Maryland, USA.
Nicolas Sluis-CremerDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Yun-Xing WangProtein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.
Rieko IshimaDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3418-0922
University of Pittsburgh · USFrederick National Laboratory for Cancer Research · USNational Institutes of Health · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI PENDLETON, RICHARD · 2019 to 2025
$3932.6M
X-Ray Core P50GM082251 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALERO, GUILLERMO ALBERTO · 2007 to 2018
$48.1M
Technology Development 2: MAS NMR and dynamic nuclear polarization for HIV-1 structural biologyP50AI150481 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRONENBORN, ANGELA M. · 2019 to 2021
$14.1M
SAXS FacilityZICBC011535 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, YUN XING M · 2014 to 2025
$7.5M
NCI NIH HHS 75N91019D00024NIAID NIH HHS P50 AI150481NIGMS NIH HHS P50 GM082251NIH HHS 75N91019D00024
6 · The paper itself

Abstract

HIV-1 reverse transcriptase (RT) is a heterodimer comprised p66 and p51 subunits (p66/p51). Several single amino acid substitutions in RT, including L289K, decrease p66/p51 dimer affinity, and reduce enzymatic functioning. Here, small-angle X-ray scattering (SAXS) with proton paramagnetic relaxation enhancement (PRE),

Indexed as

HIV Reverse TranscriptaseMutation, MissenseScattering, Small AngleX-Ray DiffractionHIV Reverse Transcriptasereverse transcriptase, Human immunodeficiency virus 1HIV-1NMRparamagnetic relaxation enhancementreverse transcriptaseSAXSstructure

Identifiers

PMID35481647
PMCPMC8996465
OpenAlexW4223586436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.