Evidence map›Paper›PMID 35481641›Full record

ArticleProtein science : a publication of the Protein Society2022

Structural insights into DNA binding domain of vancomycin-resistance-associated response regulator in complex with its promoter DNA from Staphylococcus aureus.

Jangam Vikram Kumar, Tien-Sheng Tseng, Yuan-Chao Lou, Shu-Yi Wei, Tsung-Han Wu, Hao-Cheng Tang, Yi-Chih Chiu, Chun-Hua Hsu, Chinpan Chen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Combatting Antibiotic-ResistantJournal of chemical information and modeling · 2024
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jangam Vikram KumarInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Tien-Sheng TsengInstitute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.
Yuan-Chao LouBiomedical Translation Research Center, Academia Sinica, Taipei, Taiwan.
Shu-Yi WeiInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Tsung-Han WuGenome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.
Hao-Cheng TangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yi-Chih ChiuGenome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.
Chun-Hua HsuGenome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.
Chinpan ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID 0000-0002-7164-0238
Institute of Biomedical Sciences, Academia Sinica · TWNational Taiwan University · TWNational Chung Hsing University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Staphylococcus aureus, vancomycin-resistance-associated response regulator (VraR) is a part of the VraSR two-component system, which is responsible for activating a cell wall-stress stimulon in response to an antibiotic that inhibits cell wall formation. Two VraR-binding sites have been identified: R1 and R2 in the vraSR operon control region. However, the binding of VraR to a promoter DNA enhancing downstream gene expression remains unclear. VraR contains a conserved N-terminal receiver domain (VraR

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcus aureusAnti-Bacterial AgentsBacterial ProteinsDNADNA-Binding ProteinsVancomycinAnti-Bacterial AgentsBacterial ProteinsDNADNA-Binding ProteinsVancomycinDNA binding domainNMRresponse regulatorStaphylococcus aureustwo-component systemvancomycin resistancex-ray crystal structure

Identifiers

PMID35481641
PMCPMC8994486
OpenAlexW4224295780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.