Evidence map›Paper›PMID 35481557›Full record

Trial reportBioelectromagnetics2022

LF-EMF Compound Block Type Signal Activates Human Neutrophilic Granulocytes In Vivo.

Jan J M Cuppen, Cristian Gradinaru, Bregje E Raap-van Sleuwen, Anna C E de Wit, Ton A A J van der Vegt, Huub F J Savelkoul

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Bioelectromagnetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jan J M CuppenUmani Medical BV, Waalre, The Netherlands.ORCID http://orcid.org/0000-0002-7972-1673
Cristian GradinaruUmani Medical BV, Waalre, The Netherlands.
Bregje E Raap-van SleuwenBernhoven Hospital, Uden, The Netherlands.
Anna C E de WitUmani Medical BV, Waalre, The Netherlands.
Ton A A J van der VegtUmani Medical BV, Waalre, The Netherlands.
Huub F J SavelkoulCell Biology and Immunology Group, Wageningen University & Research, Wageningen, The Netherlands.ORCID https://orcid.org/0000-0001-6236-7092
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLWageningen University & Research · NLZiekenhuis Bernhoven · NL

Funding

ZonMw 10430042010056
6 · The paper itself

Abstract

This research aims to demonstrate in a randomized, placebo-controlled crossover design study that a nominal 5 μT low-frequency electromagnetic field (LF-EMF) signal for 30 min activates neutrophils in vivo in humans. Granularity of neutrophils was measured in blood samples of healthy human volunteers (n = 32) taken before and after exposure for both the exposure and control sessions. A significant decrease in the granularity, indicative of neutrophil activation, was observed both in the exposure measurements and the exposure minus control measurements. Earlier EMF publications show immune function increase in isolated cells and more effective immune responses in animals with infections. This result, therefore, supports the thesis that the exposure can activate the innate immune system in humans, speed up the innate immune response, and may have potential beneficial effects in infectious disease. © 2022 Bioelectromagnetics Society.

Indexed as

Electromagnetic FieldsNeutrophilsAnimalsHumansinfectious diseaseinnate immune systemLF-EMFneutrophils

Identifiers

PMID35481557
PMCPMC9324799
OpenAlexW4225091071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.