Evidence map›Paper›PMID 35481419›Full record

ArticleThe Journal of international medical research2022

Piperlongumine combined with vitamin C as a new adjuvant therapy against gastric cancer regulates the ROS-STAT3 pathway.

Di Chen, Xinyue Wei, Ke Yang, Xinyue Liu, Yujin Song, Futing Bai, Yi Jiang, Yuhang Guo, Rajiv Kumar Jha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Di ChenInstitute of Basic Medical Sciences, Xi'an Medical University, Xi'an, Shaanxi Province, China.
Xinyue WeiInstitute of Basic Medical Sciences, Xi'an Medical University, Xi'an, Shaanxi Province, China.
Ke YangInstitute of Basic Medical Sciences, Xi'an Medical University, Xi'an, Shaanxi Province, China.
Xinyue LiuInstitute of Basic Medical Sciences, Xi'an Medical University, Xi'an, Shaanxi Province, China.
Yujin SongInstitute of Basic Medical Sciences, Xi'an Medical University, Xi'an, Shaanxi Province, China.
Futing BaiInstitute of Basic Medical Sciences, Xi'an Medical University, Xi'an, Shaanxi Province, China.
Yi JiangInstitute of Basic Medical Sciences, Xi'an Medical University, Xi'an, Shaanxi Province, China.
Yuhang GuoInstitute of Basic Medical Sciences, Xi'an Medical University, Xi'an, Shaanxi Province, China.
Rajiv Kumar JhaChina-Nepal Friendship Medical Research Centre of Rajiv Kumar Jha, School of Clinical Medicine, Xi'an Medical University, Xi'an, Shaanxi Province, China.ORCID https://orcid.org/0000-0001-5151-9767
Xi'an Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects of piperlongumine (PL) and vitamin C (VC) on signal transducer and activator of transcription 3 (STAT3) signalling in gastric cancer cell lines.

methods

resultsBoth PL and VC induced apoptosis and inhibited cell proliferation in AGS and KATO III cells. These effects were dependent on reactive oxygen species (ROS). PL effectively suppressed STAT3 activation while VC caused abnormal activation of STAT3. The combination of PL and VC exhibited a stronger apoptotic effect compared with either agent alone. PL reversed the abnormal activation of STAT3 by VC, which could be a key to their synergistic effect.

conclusionsPL combined with VC exhibited a stronger anticancer effect by regulating the ROS-STAT3 pathway, suggesting that this combination might be a potential adjuvant therapy for gastric cancer.

Indexed as

STAT3 Transcription FactorStomach NeoplasmsAscorbic AcidCell Line, TumorChemotherapy, AdjuvantDioxolanesHumansPiperidonesReactive Oxygen SpeciesAscorbic AcidDioxolanesPiperidonespiperlongumineReactive Oxygen SpeciesSTAT3 protein, humanSTAT3 Transcription FactorapoptosisGastric cancerpiperlonguminereactive oxygen speciessignal transducer and activator of transcription 3vitamin C

Identifiers

PMID35481419
PMCPMC9087272
OpenAlexW4224992972

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.