Evidence map›Paper›PMID 35481270›Full record

ArticleFrontiers in neurology2022

Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein.

Matthias Höllerhage, Markus Stepath, Michael Kohl, Kathy Pfeiffer, Oscar Wing Ho Chua, Linghan Duan, Franziska Hopfner, Martin Eisenacher, Katrin Marcus, Günter U Höglinger

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Matthias HöllerhageDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Markus StepathMedical Faculty, Medizinisches Proteom-Center, Ruhr University Bochum, Bochum, Germany.
Michael KohlMedical Faculty, Medizinisches Proteom-Center, Ruhr University Bochum, Bochum, Germany.
Kathy PfeifferMedical Faculty, Medizinisches Proteom-Center, Ruhr University Bochum, Bochum, Germany.
Oscar Wing Ho ChuaDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Linghan DuanDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Franziska HopfnerDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Martin EisenacherMedical Faculty, Medizinisches Proteom-Center, Ruhr University Bochum, Bochum, Germany.
Katrin MarcusMedical Faculty, Medizinisches Proteom-Center, Ruhr University Bochum, Bochum, Germany.
Günter U HöglingerDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Medizinische Hochschule Hannover · DERuhr University Bochum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LUHMES cells share many characteristics with human dopaminergic neurons in the substantia nigra, the cells, the demise of which is responsible for the motor symptoms in Parkinson's disease (PD). LUHMES cells can, therefore, be used

Indexed as

alpha-synucleinlysosomeParkinson's diseaseproteomesynapsetranscriptomevesicular transport

Identifiers

PMID35481270
PMCPMC9037753
OpenAlexW4223519321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.