ArticleRSC advances2021
Mineralization of calcium phosphate induced by a silk fibroin film under different biological conditions.
Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- From passive fillers to active implants: A 3D-printed trilayer piezoelectric scaffold recapitulating native bone hierarchy.Bioactive materials · 2027Article
- Engineering biomimetic silk fibroin hydrogel scaffolds with "organic-inorganic assembly" strategy for rapid bone regeneration.Bioactive materials · 2024Article
- Silk fibroin scaffolds: A promising candidate for bone regeneration.Frontiers in bioengineering and biotechnology · 2022Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silk fibroin is a promising biomaterial that has been used for tissue engineering applications. However, the influence of silk fibroin on the mineralization of calcium phosphate in different biological environments has not been discussed before. In this work, we fabricated organized silk fibroin film as the organic framework and amorphous calcium phosphate (ACP) deposited on the films as precursors. The transformation pathways and morphology of ACP was then studied in both enzyme and PBS (phosphate buffer saline) solutions. While only hydroxyapatite (HA) crystals formed in enzyme solution, a mixture of tricalcium phosphate (TCP) and HA crystals were obtained in PBS solution, which can be related to the variations of the content of silk fibroin and pH of the solution. Therefore, silk fibroin films can have an important effect on the mineralization process of calcium phosphate in different biological environments. In addition, cell cultivation experiments show that the silk films after mineralization promoted osteogenesis and exhibited good biocompatibility.
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Registered trials
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