ReviewRSC advances2021
Copper as an antimicrobial agent: recent advances.
Review in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
142 citing papers in PubMed, 2 syntheses or guidelines pooled it, 385 citations in OpenAlex.
- Awareness of Microbiological Safety in Playgrounds Amid Rising Antibiotic Resistance.Environmental microbiology reports · 2025Pooled it
- A Matter of Metals: Copper but Not Cadmium Affects the Microbial Alpha-Diversity of Soils and Sediments - a Meta-analysis.Microbial ecology · 2023Pooled it
- Bromide-mediated pathway modulation enables energy-efficient electrosynthesis of ultralight hierarchical copper powder.RSC advances · 2026Article
- Antibacterial surface engineering: bioinspiration from leaves to medical devices.RSC applied interfaces · 2026Review
- Antibiotic-Free Strategies for Managing Antimicrobial-Resistant Infections.Pharmaceutics · 2026Review
- Structurally Engineered Cu(II)-4-Chloro-2-nitrobenzoate-Picoline Complexes Immobilized in PVA/Cellulose Composite Films for Sustainable Catalytic and Antimicrobial Applications.ACS polymers Au · 2026Article
- Covalently Immobilized Lignin-Xanthene Conjugates for Persistent Surface Photochemistry and Self-Sterilizing Interfaces Under Ambient Visible Light.Macromolecular rapid communications · 2026Article
- Synthesis of a Novel Cone-like Tenorite-Antlerite Nanocomposite and Assessment of Its Photocatalytic and Antibacterial Activity.ACS omega · 2026Article
- Copper Compounds: A Narrative and Regulatory Review of Agricultural Uses, Risks, and Environmental Assessment.Toxics · 2026Review
- Bacterial sensitivity distributions for biocides and metals.FEMS microbiology ecology · 2026Article
- Copper-Doped Silicate Porous Architectures for Hard Tissue Engineering.Journal of functional biomaterials · 2026Article
- Coordination Metal Complexes With Antibacterial and Antioxidant Functions for Food Packaging: From Single-Function Systems to Intelligent Materials.Comprehensive reviews in food science and food safety · 2026Review
- Copper Integrated PDA-TA Nanocoating via One-Step Rapid Polymerization on Titanium for Anti-Thrombotic and Antibacterial Properties.Biomolecules · 2026Article
- Data-Driven Engineering of Antimicrobial Nanomaterials for Food Safety and Biomedical Systems.Nanomaterials (Basel, Switzerland) · 2026Review
- Antifungal Activity of Conjugated Metal Organic Frameworks: A Multidisciplinary Undergraduate Laboratory Experiment.Journal of chemical education · 2026Article
- Differences in Textile Metal Threads in Croatia Through the Centuries.Materials (Basel, Switzerland) · 2026Article
- Whisky-Inspired Active Matter.ACS applied materials & interfaces · 2026Article
- The Two Faces of Copper Capture Driven by the Internal His/Met-Rich and N-Terminal His-Rich Domains of CopI.Inorganic chemistry · 2026Article
- Low Percent Copper Doping Limits Bacterial Adhesion on Fluorapatite-Based Bone Scaffolds.Journal of biomedical materials research. Part B, Applied biomaterials · 2026Article
- Structure-Driven Bioactivity of Chitosan-Agarose-Gelatin Hydrogels Functionalized with Tannic Acid-CuACS applied materials & interfaces · 2026Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From its uses in ancient civilisations, copper has an established history as an antimicrobial agent. Extensive research has determined the efficacy and mechanism of copper's antimicrobial activity against microorganisms. The process is multifaceted with the main mechanism of bactericidal activity being the generation of reactive oxygen species (ROS), which irreversibly damages membranes. Copper ions released from surfaces lead to RNA degradation and membrane disruption of enveloped viruses. For fungi, the mechanism involves the physical deterioration of the membrane and copper ion influx. Due to variations in the experimental parameters, it is difficult to compare studies directly. In this review article, we outline the importance of the experimental conditions currently employed and how they bear little resemblance to real-world conditions. We endorse previous recommendations calling for an update to industrial standard tests.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.