Evidence map›Paper›PMID 35480861›Full record

ArticleRegenerative biomaterials2022

Yes-associated protein contributes to magnesium alloy-derivedinflammation in endothelial cells.

Hongchi Yu, Zhe Hou, Nuoya Chen, Rifang Luo, Li Yang, Michael Miao, Xiaoyi Ma, Lifeng Zhou, Fugui He, Yang Shen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The mPediatric surgery international · 2023
    Article
  5. Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Hongchi YuNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Zhe HouNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Nuoya ChenNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Rifang LuoNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Li YangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Michael MiaoDivision of Oral & Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC 27599, USA.
Xiaoyi MaBeijing Key Laboratory of Cardiac Drug Device Technology and Evidence Based Medicine, Beijing 100021, China.
Lifeng ZhouBeijing Key Laboratory of Cardiac Drug Device Technology and Evidence Based Medicine, Beijing 100021, China.
Fugui HeBeijing Key Laboratory of Cardiac Drug Device Technology and Evidence Based Medicine, Beijing 100021, China.
Yang ShenInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
Xiaoheng LiuInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
Yunbing WangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Sichuan University · CNWest China Medical Center of Sichuan University · CNUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnesium alloy (Mg alloy) has attracted massive attention in the potential applications of cardiovascular stents because of its good biocompatibility and degradability. However, whether and how the Mg alloy induces inflammation in endothelial cells remains unclear. In the present work, we investigated the activation of Yes-associated protein (YAP) upon Mg alloy stimuli and unveiled the transcriptional function in Mg alloy-induced inflammation. Quantitative RT-PCR, western blotting and immunofluorescence staining showed that Mg alloy inhibited the Hippo pathway to facilitate nuclear shuttling and activation of YAP in human coronary artery endothelial cells (HCAECs). Chromatin immunoprecipitation followed sequencing was carried out to explore the transcriptional function of YAP in Mg alloy-derived inflammation. This led to the observation that nuclear YAP further bonded to the promoter region of inflammation transcription factors and co-transcription factors. This binding event activated their transcription and modified mRNA methylation of inflammation-related genes through regulating the expression of N6-methyladenosine modulators (

Indexed as

inflammationmagnesium alloyYes-associated protein

Identifiers

PMID35480861
PMCPMC9039498
OpenAlexW4206706385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.