ArticleRSC advances2021
Self-assemblies of pluronic micelles in partitioning of anticancer drugs and effectiveness of this system towards target protein.
Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
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- Exploring the Limits of Passive Macromolecular Translocation through Phospholipid Membranes.Biomacromolecules · 2025Article
- Poloxamer-based drug delivery systems: Frontiers for treatment of solid tumors.Materials today. Bio · 2025Review
- Nanotechnological Formulation IncorporatingPolymers · 2025Article
- Programmable phase transition enables tunable microstructures and micromechanics in thermoresponsive polysaccharide hydrogels.Communications materials · 2025Article
- Tunable network architecture in a hydrogel with extreme vibration damping properties.Communications materials · 2025Article
- Development of an Eco-Friendly Nanogel IncorporatingPharmaceutics · 2024Article
- Mixed Micellar Gel of Poloxamer Mixture for Improved Solubilization of Poorly Water-Soluble Ibuprofen and Use as Thermosensitive In Situ Gel.Pharmaceutics · 2024Article
- Real-Time Tunable Gas Sensing Platform Based on SnONano-micro letters · 2024Article
- Poloxamer-Based Mixed Micelles Loaded with Thymol or Eugenol for Topical Applications.ACS omega · 2024Article
- Old drug, new tricks: polymer-based nanoscale systems for effective cytarabine delivery.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Gemcitabine-Vitamin E Prodrug-Loaded Micelles for Pancreatic Cancer Therapy.Pharmaceutics · 2024Article
- Pluronic F-68 and F-127 Based Nanomedicines for Advancing Combination Cancer Therapy.Pharmaceutics · 2023Review
- Article
- Nano Differential Scanning Fluorimetry as a Rapid Stability Assessment Tool in the Nanoformulation of Proteins.Pharmaceutics · 2023Article
- Direct and Reverse Pluronic Micelles: Design and Characterization of Promising Drug Delivery Nanosystems.Pharmaceutics · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micelles formed by pluronic triblock copolymers are known to be a promising class of drug delivery vehicles. Quantitative mechanistic insights into the ability of pluronic micelles to improve the solubility of poorly water soluble drugs, encapsulation and delivery of hydrophilic drugs are not available. The current study evaluated the energetics of encapsulation of chemotherapeutic drugs gemcitabine, cytarabine, and hydroxyurea in pluronic F127 and F68 micelles. In addition, the interactions of the drugs released from pluronic micellar media with serum albumin, which is a major circulatory transport protein, and subsequent conformational changes have also been analyzed with the help of calorimetry and spectroscopy. All the drugs showed improved partitioning in F127 micelles, the extent of which slightly increased with temperature rise. Interestingly, drug-protein binding is enhanced upon delivery from pluronic micelles without affecting the conformational integrity of the protein. This study highlights the role of drug functionalities, hydrophobicity, and steric factors towards their partitioning in pluronic micelles. Such studies are important in understanding physicochemical aspects of drug encapsulation and release, and lead to establishing structure-property-energetics correlations for developing suitable nano-drug delivery vehicles.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.