Evidence map›Paper›PMID 35480626›Full record

ArticleCell reports. Medicine2022

Consumer-grade wearables identify changes in multiple physiological systems during COVID-19 disease progression.

Caleb Mayer, Jonathan Tyler, Yu Fang, Christopher Flora, Elena Frank, Muneesh Tewari, Sung Won Choi, Srijan Sen, Daniel B Forger

2 registry-linked trialsAbstract read
In one paragraph

Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06207929 completednot on this mapstarted 2024, after this paper: background citation

Wearable Assisted Viral Evidence (WAVE) Study A Decentralized, Prospective Study Exploring the Relationship Between Passively-collected Data From Wearable Activity Devices and Respiratory Viral Infections

TypeobservationalSponsorEvidation HealthRan2024 to 2024Enrolled18,157ConditionsInfluenza, Human, COVID-19, Influenza A, Influenza B
NCT06229444 nacompletednot on this mapstarted 2024, after this paper: background citation

Predict + Protect: A Randomized Controlled Trial Exploring the Effectiveness of a Predictive Health Education Intervention on the Adoption of Protective Behaviors Related to Influenza-like Illness (ILI)

TypeinterventionalSponsorEvidation HealthRan2024 to 2024Enrolled17,043ConditionsInfluenza, Influenza A, Influenza B, COVID-19ArmsILI Predictive Alerts, Reactive Content, and Proactive Content, ILI Predictive Alerts, Reactive Content, Proactive Content, No Intervention
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
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  10. Integrative Analysis of Rhythmicity: From Biology to Urban Environments and Sustainability.International journal of environmental research and public health · 2022
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caleb MayerDepartment of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA.
Jonathan TylerDepartment of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Yu FangMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Christopher FloraDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Elena FrankMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Muneesh TewariDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Sung Won ChoiDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Srijan SenMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Daniel B ForgerDepartment of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: forger@umich.edu.

Funding

Training Program in Molecular HematologyT32HL007622 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUNG WON CHOI, Jordan A. Shavit · 1986 to 2026
$9.2M
Phase I/II clinical trial of HDAC inhibition for GVHD prevention in children, adolescents, and young adultsR01CA249211 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHOI, SUNG WON · 2020 to 2024
$2.2M
Roadmap 2.0: A randomized controlled trial using a technology-mediated platform in family caregivers of BMT patientsR01HL146354 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHOI, SUNG WON · 2019 to 2023
$1.8M
Patient-Oriented Research and Mentoring in Hematopoietic Cell TransplantationK24HL156896 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUNG WON CHOI · 2021 to 2026
$870k
NCI NIH HHS R01 CA249211NHLBI NIH HHS K24 HL156896NHLBI NIH HHS R01 HL146354NHLBI NIH HHS T32 HL007622
6 · The paper itself

Abstract

Consumer-grade wearables are needed to track disease, especially in the ongoing pandemic, as they can monitor patients in real time. We show that decomposing heart rate from low-cost wearable technologies into signals from different systems can give a multidimensional description of physiological changes due to COVID-19 infection. We find that the separate physiological features of basal heart rate, heart rate response to physical activity, circadian variation in heart rate, and autocorrelation of heart rate are significantly altered and can classify symptomatic versus healthy periods. Increased heart rate and autocorrelation begin at symptom onset, while the heart rate response to activity increases soon after symptom onset and increases more in individuals exhibiting cough. Symptom onset is associated with a blunting of circadian variation in heart rate, as measured by the uncertainty in the phase estimate. This work establishes an innovative data analytic approach to monitor disease progression remotely using consumer-grade wearables.

Indexed as

COVID-19Wearable Electronic DevicesDisease ProgressionHeart RateHumansMonitoring, Physiologiccircadian rhythmsCOVID-19disease monitoringheart ratemathematical modelingwearables

Identifiers

PMID35480626
PMCPMC9017023

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.