Evidence map›Paper›PMID 35480561›Full record

ArticlePeerJ2022

lncRNA MALAT1 mediates osteogenic differentiation of bone mesenchymal stem cells by sponging miR-129-5p.

Junhao Yin, Zhanglong Zheng, Xiaoli Zeng, Yijie Zhao, Zexin Ai, Miao Yu, Yang'ou Wu, Jirui Jiang, Jia Li, Shengjiao Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. LINC01271 promotes fracture healing via regulating miR-19a-3p/PIK3CA axis.Journal of orthopaedic surgery and research · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junhao Yin *Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tongji University, Shanghai, China.
Zhanglong Zheng *Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tongji University, Shanghai, China.
Xiaoli ZengDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tongji University, Shanghai, China.
Yijie ZhaoShanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.
Zexin AiDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tongji University, Shanghai, China.
Miao YuDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tongji University, Shanghai, China.
Yang'ou WuShanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.
Jirui JiangDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tongji University, Shanghai, China.
Jia LiShanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.
Shengjiao LiDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bone mesenchymal stem cells (BMSCs) have good osteogenic differentiation potential and have become ideal seed cells in bone tissue engineering. However, the osteogenic differentiation ability of BMSCs gradually weakens with age, and the regulatory mechanism is unclear. Method: We conducted a bioinformatics analysis, dual-luciferase reporter (DLR) experiment, and RNA binding protein immunoprecipitation (RIP) to explore the hub genes that may affect BMSC functions. Results: The expression level of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 ( Conclusion: Overall, our study findings indicated that lncRNA

Indexed as

Mesenchymal Stem CellsMicroRNAsOsteogenesisRNA, Long NoncodingAnimalsCell DifferentiationMiceMalat1 long non-coding RNA, mouseMicroRNAsMIRN129 microRNA, mouseRNA, Long NoncodingBone mesenchymal stem cellsMALAT1miR-129-5pOsteoblast differentiation

Identifiers

PMID35480561
PMCPMC9037136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.