Evidence map›Paper›PMID 35480232›Full record

ArticleFrontiers in cellular and infection microbiology2022

Utility of Multi-target Nested PCR and ELISPOT Assays for the Detection of Paucibacillary Leprosy: A Possible Conclusion of Clinical Laboratory Misdiagnosis.

Haiqin Jiang, Ying Shi, Santosh Chokkakula, Wenyue Zhang, Siyu Long, Zhenzhen Wang, Wenming Kong, Heng Long, Limei Wu, Lihua Hu and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Target product profiles: leprosy diagnostics.Bulletin of the World Health Organization · 2024
    Article
  5. qPCR detection ofFrontiers in molecular biosciences · 2024
    Article
  6. Article
  7. Challenges and advances in serological and molecular tests to aid leprosy diagnosis.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Haiqin JiangDepartment of Mycobacterium, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Ying ShiDepartment of Mycobacterium, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Santosh ChokkakulaDepartment of Mycobacterium, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Wenyue ZhangDepartment of Mycobacterium, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Siyu LongDepartment of Mycobacterium, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Zhenzhen WangDepartment of Mycobacterium, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Wenming KongDepartment of Leprosy Control, Zhejiang, Provincial Institute of Dermatology, Zhejiang, China.
Heng LongDepartment of Leprosy Control, Wenshan institute of Dermatology, Wenshan, China.
Limei WuDepartment of Leprosy Control, Zhejiang, Provincial Institute of Dermatology, Zhejiang, China.
Lihua HuDepartment of Leprosy Control, Zhejiang, Provincial Institute of Dermatology, Zhejiang, China.
Qiang YaoDepartment of Leprosy Control, Zhejiang, Provincial Institute of Dermatology, Zhejiang, China.
Hongsheng WangDepartment of Mycobacterium, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
National Center for AIDS/STD Control and Prevention,China CDC · CNChinese Academy of Medical Sciences Dermatology Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNNanjing Medical University · CNWenshan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis of paucibacillary (PB) leprosy often possesses a diagnostic challenge, especially for pure neuritic and lesser skin lesions with the zero bacillary load, requiring a sensitive and accurate diagnostic tool. We have included 300 clinically diagnosed new leprosy cases (comprising 98 PB cases) and analyzed the sensitivity and specificity of PB leprosy cases by nested PCR with

Indexed as

LeprosyLeprosy, PaucibacillaryDiagnostic ErrorsEnzyme-Linked Immunospot AssayHumansInterferon-gammaLaboratories, ClinicalMycobacterium lepraePolymerase Chain ReactionInterferon-gammadiagnosisELISPOTnested PCRpaucibacillary leprosyPCR

Identifiers

PMID35480232
PMCPMC9036522
OpenAlexW4223552313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.