Evidence map›Paper›PMID 35480199›Full record

ArticleRSC advances2021

Pd-catalyzed synthesis of 1-(hetero)aryl-2,2,2-trichloroethanols using chloral hydrate and (hetero)arylboroxines.

Minori Shimizu, Yuta Okuda, Koki Toyoda, Ryo Akiyama, Hiraku Shinozaki, Tetsuya Yamamoto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Minori ShimizuDepartment of Materials and Life Sciences, Tokyo Denki University 5 Senju-Asahicho Adachi Tokyo 120-8551 Japan t-yamamoto@mail.dendai.ac.jp.
Yuta OkudaDepartment of Materials Science and Engineering, Tokyo Denki University 5 Senju-Asahicho, Adachi-ku Tokyo 120-8551 Japan.
Koki ToyodaDepartment of Applied Chemistry, Tokyo Denki University 5 Senju-Asahicho, Adachi-ku Tokyo 120-8551 Japan.
Ryo AkiyamaDepartment of Materials Science and Engineering, Tokyo Denki University 5 Senju-Asahicho, Adachi-ku Tokyo 120-8551 Japan.
Hiraku ShinozakiDepartment of Applied Chemistry, Tokyo Denki University 5 Senju-Asahicho, Adachi-ku Tokyo 120-8551 Japan.
Tetsuya YamamotoDepartment of Materials and Life Sciences, Tokyo Denki University 5 Senju-Asahicho Adachi Tokyo 120-8551 Japan t-yamamoto@mail.dendai.ac.jp.ORCID https://orcid.org/0000-0002-1951-8956
Tokyo Denki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1-(Hetero)aryl-2,2,2-trichloroethanols are useful key intermediates for the synthesis of various bioactive compounds. Herein, we describe N-heterocyclic carbene (NHC)-coordinated cyclometallated palladium complex (CYP)-catalyzed (hetero)aryl addition of chloral hydrate using (hetero)arylboroxines, providing a new approach to 1-(hetero)aryl-2,2,2-trichloroethanols. Notably, PhS-IPent-CYP which coordinated the bulky yet flexible 2,6-di(pentan-3-yl)aniline (IPent)-based NHC showed good catalytic activities and promoted the transformation in 24-97% yields.

Identifiers

PMID35480199
PMCPMC9033206
OpenAlexW3162412176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.