Evidence map›Paper›PMID 35480175›Full record

ArticleRSC advances2021

A PCR-free screen-printed magnetic electrode for the detection of circular RNA from hepatocellular cancer based on a back-splice junction.

Bin Zhang, Yitao Liang, Liang Bo, Mingyu Chen, Bobo Huang, Qingpeng Cao, Jinwei Wei, Tianyu Li, Xiujun Cai, Xuesong Ye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Bin ZhangBiosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Innovation Centre for Minimally Invasive Technique and Device, Zhejiang University Hangzhou 310027 PR China yexuesong@zju.edu.cn +86 571 87952756.ORCID https://orcid.org/0000-0002-6888-811X
Yitao LiangBiosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Innovation Centre for Minimally Invasive Technique and Device, Zhejiang University Hangzhou 310027 PR China yexuesong@zju.edu.cn +86 571 87952756.ORCID https://orcid.org/0000-0002-4814-1350
Liang BoBiosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Innovation Centre for Minimally Invasive Technique and Device, Zhejiang University Hangzhou 310027 PR China yexuesong@zju.edu.cn +86 571 87952756.ORCID https://orcid.org/0000-0002-3670-2296
Mingyu ChenDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University 3 East Qingchun Road Hangzhou 310016 PR China srrsh_cxj@zju.edu.cn +86 571 86006617.
Bobo HuangBiosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Innovation Centre for Minimally Invasive Technique and Device, Zhejiang University Hangzhou 310027 PR China yexuesong@zju.edu.cn +86 571 87952756.
Qingpeng CaoBiosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Innovation Centre for Minimally Invasive Technique and Device, Zhejiang University Hangzhou 310027 PR China yexuesong@zju.edu.cn +86 571 87952756.ORCID https://orcid.org/0000-0002-1492-4680
Jinwei WeiBiosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Innovation Centre for Minimally Invasive Technique and Device, Zhejiang University Hangzhou 310027 PR China yexuesong@zju.edu.cn +86 571 87952756.
Tianyu LiBiosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Innovation Centre for Minimally Invasive Technique and Device, Zhejiang University Hangzhou 310027 PR China yexuesong@zju.edu.cn +86 571 87952756.
Xiujun CaiDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University 3 East Qingchun Road Hangzhou 310016 PR China srrsh_cxj@zju.edu.cn +86 571 86006617.
Xuesong YeBiosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Innovation Centre for Minimally Invasive Technique and Device, Zhejiang University Hangzhou 310027 PR China yexuesong@zju.edu.cn +86 571 87952756.ORCID https://orcid.org/0000-0002-3439-3733
Ministry of Education of the People's Republic of China · CNSir Run Run Shaw Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA (circRNA) has the potential to be applied to disease diagnosis and therapy. However, the currently available circRNA detection techniques are limited. This work proposes a sensitive and selective approach for circRNA detection based on gold nanoparticle-modified screen-printed magnetic electrodes (AuNPs-SPME). Magnetic beads (MBs) with capture probes based on specific back-splice junction (BSJ) sites were employed to identify and selectively isolate the target circRNA, which could be directly adsorbed onto the AuNPs-SPME. Then, the circRNA attached to the surface was detected by changes in the methylene blue redox signal. The simple and time-saving AuNPs-SPME is highly sensitive (LOD = 1.0 pM) to circCDYL, one of the biomarkers of hepatocellular cancer (HCC). The analytical performance of the method presented has also been verified in human serum samples, holding great promise for clinical diagnosis.

Identifiers

PMID35480175
PMCPMC9033221
OpenAlexW3161553473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.