Evidence map›Paper›PMID 35480142›Full record

ArticleBioMed research international2022

Structural Configuration of Blood Cell Membranes Determines Their Nonlinear Deformation Properties.

Elena Kozlova, Viktoria Sergunova, Vladimir Inozemtsev, Ekaterina Sherstyukova, Aleksandr Kozlov, Olga Gudkova, Aleksandr Chernysh

Abstract read
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elena KozlovaLaboratory of Biophysics of Cell Membrane under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, Moscow 107031, Russia.ORCID https://orcid.org/0000-0002-1780-895X
Viktoria SergunovaLaboratory of Biophysics of Cell Membrane under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, Moscow 107031, Russia.ORCID https://orcid.org/0000-0002-8425-0845
Vladimir InozemtsevLaboratory of Biophysics of Cell Membrane under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, Moscow 107031, Russia.ORCID https://orcid.org/0000-0002-4693-5624
Ekaterina SherstyukovaLaboratory of Biophysics of Cell Membrane under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, Moscow 107031, Russia.ORCID https://orcid.org/0000-0002-9962-6315
Aleksandr KozlovDepartment of Medical and Biological Physics, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia.ORCID https://orcid.org/0000-0003-3907-080X
Olga GudkovaLaboratory of Biophysics of Cell Membrane under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, Moscow 107031, Russia.ORCID https://orcid.org/0000-0001-9220-0138
Aleksandr ChernyshLaboratory of Biophysics of Cell Membrane under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, Moscow 107031, Russia.ORCID https://orcid.org/0000-0002-8292-5909

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of neutrophils and red blood cells (RBCs) to undergo significant deformations is a key to their normal functioning. Disruptions of these processes can lead to pathologies. This work studied the influence of structural configuration rearrangements of membranes after exposure to external factors on the ability of native membranes of neutrophils and RBCs to undergo deep deformation. The rearrangement of the structural configuration of neutrophil and RBC membranes under the influence of cytological fixatives caused nonlinear deformation phenomena. There were an increase in Young's modulus, a decrease in the depth of homogeneous bending, and a change in the distance between cytoskeletal junctions. Based on the results of the analysis of experimental data, a mathematical model was proposed that describes the process of deep bending of RBСs and neutrophil membranes.

Indexed as

ErythrocytesNeutrophilsCell MembraneCytoskeletonElastic Modulus

Identifiers

PMID35480142
PMCPMC9038403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.