Evidence map›Paper›PMID 35480116›Full record

ArticleFrontiers in oncology2022

Cancer Progression Gene Expression Profiling Identifies the Urokinase Plasminogen Activator Receptor as a Biomarker of Metastasis in Cutaneous Squamous Cell Carcinoma.

Elahe Minaei, Simon A Mueller, Bruce Ashford, Amarinder Singh Thind, Jenny Mitchell, Jay R Perry, Benjamin Genenger, Jonathan R Clark, Ruta Gupta, Marie Ranson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Imaging transcriptomics in basal cell carcinoma: Coupling in vivo tumor morphology with gene expression.JID innovations : skin science from molecules to population health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Elahe MinaeiIllawarra Health and Medical Research Institute (IHMRI), Wollongong, NSW, Australia.
Simon A MuellerDepartment of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, NSW, Australia.
Bruce AshfordIllawarra Health and Medical Research Institute (IHMRI), Wollongong, NSW, Australia.
Amarinder Singh ThindIllawarra Health and Medical Research Institute (IHMRI), Wollongong, NSW, Australia.
Jenny MitchellIllawarra and Shoalhaven Local Health District (ISLHD), Wollongong, NSW, Australia.
Jay R PerryIllawarra Health and Medical Research Institute (IHMRI), Wollongong, NSW, Australia.
Benjamin GenengerIllawarra Health and Medical Research Institute (IHMRI), Wollongong, NSW, Australia.
Jonathan R ClarkDepartment of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, NSW, Australia.
Ruta GuptaDepartment of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, NSW, Australia.
Marie RansonIllawarra Health and Medical Research Institute (IHMRI), Wollongong, NSW, Australia.
University of Wollongong · AUChris O’Brien Lifehouse · AUIllawarra Health and Medical Research Institute · AUIllawarra Shoalhaven Local Health District · AURoyal Prince Alfred Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (cSCC) of the head and neck region is the second most prevalent skin cancer, with metastases to regional lymph nodes occurring in 2%-5% of cases. To further our understanding of the molecular events characterizing cSCC invasion and metastasis, we conducted targeted cancer progression gene expression and pathway analysis in non-metastasizing (PRI-) and metastasizing primary (PRI+) cSCC tumors of the head and neck region, cognate lymph node metastases (MET), and matched sun-exposed skin (SES). The highest differentially expressed genes in metastatic (MET and PRI+) versus non-metastatic tumors (PRI-) and SES included

Indexed as

cutaneous squamous cell carcinoma (cSSC)extracellular matrix (ECM)matrix metalloproteinase (MMP)metastasistranscriptomicstumor stromaurokinase plasminogen activator receptor (uPAR)urokinase plasminogen activator (uPA)

Identifiers

PMID35480116
PMCPMC9035872
OpenAlexW4223528413

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.