ArticleEClinicalMedicine2022
Associations of dynamic driving pressure and mechanical power with postoperative pulmonary complications-posthoc analysis of two randomised clinical trials in open abdominal surgery.
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Protective Ventilation With Higher Versus Lower PEEP During General Anesthesia for Surgery in Obese Patients
Association of Intraoperative Mechanical Power With Postoperative Pulmonary Complications and Prolonged Mechanical Ventilation in Coronary Artery Bypass Graft Surgery
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Mechanical Power and the Association with Postoperative Impaired Oxygenation and Pulmonary Complications in Orthopedic Patients: Post Hoc Analysis of a Cluster Factorial Randomized Trial.Anesthesiology · 2026Trial
- Mechanical power during one-lung ventilation is associated with postoperative pulmonary complications in patients undergoing lobectomy: a single-center prospective cohort study.BMC anesthesiology · 2026Trial
- Driving pressure guided ventilation with lung ultrasound reduces pulmonary complications after epigastric surgery at high altitude.Scientific reports · 2026Trial
- Effect of intravenous vs. inhaled penehyclidine on respiratory mechanics in patients during one-lung ventilation for thoracoscopic surgery: a prospective, double-blind, randomised controlled trial.BMC pulmonary medicine · 2023Trial
- Airway-derived mechanical power and postoperative pulmonary complications in obese adults undergoing laparoscopic bariatric surgery: a secondary analysis of a randomised trial.Journal of anesthesia · 2026Article
- Individual and combined effects of chemical and mechanical power on postoperative pulmonary complications: a secondary analysis of the REPEAT study.Anaesthesia · 2025Article
- Association of intraoperative mechanical power of ventilation with occurrence of postoperative respiratory failure in patients undergoing major abdominal onco-surgery in a tertiary cancer centre - A prospective analytical study.Indian journal of anaesthesia · 2025Article
- Postoperative Pulmonary Complications in Conventional Laparoscopic vs Robot-Assisted Abdominal Surgery.JAMA surgery · 2025Article
- Mechanical power in patients receiving mechanical ventilation in the surgical intensive care unit and its association with increased mortality: a retrospective cohort study.BMJ open respiratory research · 2025Article
- Observational
- Predicting postoperative pulmonary infection in elderly patients undergoing major surgery: a study based on logistic regression and machine learning models.BMC pulmonary medicine · 2025Article
- Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients.Annals of intensive care · 2025Article
- Correlations between primary tumour location, biomarkers of inflammation and lung injury, and postoperative pulmonary complications in patients underwent laparoscopic colorectomy: a propensity score matched analysis of 300 patients.Frontiers in immunology · 2025Article
- Impact of mechanical power on ICU mortality in ventilated critically ill patients: a retrospective study with continuous real-life data.European journal of medical research · 2024Observational
- Mechanical power during robotic-assisted laparoscopic prostatectomy: an observational study.Journal of clinical monitoring and computing · 2024Observational
- Intraoperative Ventilation/Perfusion Mismatch and Postoperative Pulmonary Complications after Major Noncardiac Surgery: A Prospective Cohort Study.Anesthesiology · 2024Article
- Driving pressure: A useful tool for reducing postoperative pulmonary complications.World journal of critical care medicine · 2024Article
- Epidemiology, ventilation management and outcomes of COVID-19 ARDS patients versus patients with ARDS due to pneumonia in the Pre-COVID era.Respiratory research · 2024Observational
- Effect of the prone position on mechanical power in elective surgical patients under general anesthesia: A prospective observational study.Saudi medical journal · 2024Observational
- Association between mechanical power during one-lung ventilation and pulmonary complications after thoracoscopic lung resection surgery: a prospective observational study.BMC anesthesiology · 2024Observational
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While an association of the intraoperative driving pressure with postoperative pulmonary complications has been described before, it is uncertain whether the intraoperative mechanical power is associated with postoperative pulmonary complications. Methods: Posthoc analysis of two international, multicentre randomised clinical trials (ISRCTN70332574 and NCT02148692) conducted between 2011-2013 and 2014-2018, in patients undergoing open abdominal surgery comparing the effect of two different positive end-expiratory pressure (PEEP) levels on postoperative pulmonary complications. Time-weighted average dynamic driving pressure and mechanical power were calculated for individual patients. A multivariable logistic regression model adjusted for confounders was used to assess the independent associations of driving pressure and mechanical power with the occurrence of a composite of postoperative pulmonary complications, the primary endpoint of this posthoc analysis. Findings: In 1191 patients included, postoperative pulmonary complications occurrence was 35.9%. Median time-weighted average driving pressure and mechanical power were 14·0 [11·0-17·0] cmH Interpretation: In this merged cohort of surgery patients, higher intraoperative mechanical power was independently associated with postoperative pulmonary complications. Mechanical power could serve as a summary ventilatory biomarker for the risk for postoperative pulmonary complications in these patients, but our findings need confirmation in other, preferably prospective studies. Funding: The two original studies were supported by unrestricted grants from the European Society of Anaesthesiology and the Amsterdam University Medical Centers, Location AMC. For this current analysis, no additional funding was requested. The funding sources had neither a role in the design, collection of data, statistical analysis, interpretation of data, writing of the report, nor in the decision to submit the paper for publication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.