Evidence map›Paper›PMID 35479870›Full record

ArticleRSC advances2021

PEGylated ethyl cellulose micelles as a nanocarrier for drug delivery.

Amarnath Singam, Naresh Killi, Pratikshkumar R Patel, Rathna V N Gundloori

Abstract read
In one paragraph

Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amarnath SingamPolymer Science and Engineering, CSIR-National Chemical Laboratory Homi Bhabha Road Pune-411008 Maharashtra India rv.gundloori@ncl.res.in.ORCID https://orcid.org/0000-0002-3185-0521
Naresh KilliPolymer Science and Engineering, CSIR-National Chemical Laboratory Homi Bhabha Road Pune-411008 Maharashtra India rv.gundloori@ncl.res.in.ORCID https://orcid.org/0000-0001-8772-6848
Pratikshkumar R PatelPolymer Science and Engineering, CSIR-National Chemical Laboratory Homi Bhabha Road Pune-411008 Maharashtra India rv.gundloori@ncl.res.in.ORCID https://orcid.org/0000-0002-2893-3721
Rathna V N GundlooriPolymer Science and Engineering, CSIR-National Chemical Laboratory Homi Bhabha Road Pune-411008 Maharashtra India rv.gundloori@ncl.res.in.ORCID https://orcid.org/0000-0002-8084-2296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural polymers provide a better alternative to synthetic polymers in the domain of drug delivery systems (DDSs) because of their renewability, biocompatibility, and low immunogenicity; therefore, they are being studied for the development of bulk/nanoformulations. Likewise, current methods for engineering natural polymers into micelles are in their infancy, and in-depth studies are required using natural polymers as controlled DDSs. Accordingly, in our present study, a new micellar DDS was synthesized using ethyl cellulose (EC) grafted with polyethylene glycol (PEG); it was characterized, its properties, cell toxicity, and hemocompatibility were evaluated, and its drug release kinetics were demonstrated using doxorubicin (DOX) as a model drug. Briefly, EC was grafted with PEG to form the amphiphilic copolymers EC-PEG1 and EC-PEG2 with varying PEG concentrations, and nano-micelles were prepared with and without the drug (DOX)

Identifiers

PMID35479870
PMCPMC9041117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.