Evidence map›Paper›PMID 35479740›Full record

ArticleFrontiers in nutrition2022

Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects.

Keisuke Okabe, Keisuke Yaku, Yoshiaki Uchida, Yuichiro Fukamizu, Toshiya Sato, Takanobu Sakurai, Kazuyuki Tobe, Takashi Nakagawa

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06991712 (Comparisons of Nicotinamide Adenine Dinucleotide), which is not on this map. Cited by 56 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 4 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06991712 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Comparisons of Nicotinamide Adenine Dinucleotide (NAD) Precursors for Neuroenhancement in Glaucoma Patients

TypeinterventionalSponsorChristopher Kai Shun LeungRan2025 to 2026Enrolled138ConditionsGlaucomaArmsNicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide, Nicotinic Acid, Placebo (Corn Starch)
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  12. Skin Cancer Prevention and Antiaging: Role of Nicotinamide.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Keisuke OkabeDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Keisuke YakuDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Yoshiaki UchidaResearch and Development Division, Mitsubishi Corporation Life Sciences Limited, Chiyoda-ku, Japan.
Yuichiro FukamizuResearch and Development Division, Mitsubishi Corporation Life Sciences Limited, Chiyoda-ku, Japan.
Toshiya SatoResearch and Development Division, Mitsubishi Corporation Life Sciences Limited, Chiyoda-ku, Japan.
Takanobu SakuraiResearch and Development Division, Mitsubishi Corporation Life Sciences Limited, Chiyoda-ku, Japan.
Kazuyuki TobeFirst Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
Takashi NakagawaDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Mitsubishi Corporation (Japan) · JPUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinamide mononucleotide (NNM) is an orally bioavailable NAD

Indexed as

agingclinical trialNADNMNsafety

Identifiers

PMID35479740
PMCPMC9036060
OpenAlexW4223527818

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.