ArticleFrontiers in microbiology2022
A One-Health Approach to Investigating an Outbreak of Alimentary Tick-Borne Encephalitis in a Non-endemic Area in France (Ain, Eastern France): A Longitudinal Serological Study in Livestock, Detection in Ticks, and the First Tick-Borne Encephalitis Virus Isolation and Molecular Characterisation.
Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- A Systematic Review on the Prevalence of Tick-Borne Encephalitis Virus in Milk and Milk Products in Europe.Zoonoses and public health · 2025Pooled it
- Systematic Review and Meta-analysis of Foodborne Tick-Borne Encephalitis, Europe, 1980-2021.Emerging infectious diseases · 2022Pooled it
- Underrecognized Tick-Borne Encephalitis in Serbia: Evidence from Patients with Suspected West Nile Virus Neuroinvasive Disease.Pathogens (Basel, Switzerland) · 2026Article
- Identification and mapping of potential and highly likely vectors for selected vector-borne diseases in the EU and neighbouring countries.EFSA journal. European Food Safety Authority · 2026Article
- A Household Cluster of Tick-Borne Encephalitis in Belgium in 2025: Is the Epidemiology Evolving?Viruses · 2026Article
- Investigation of tick-borne encephalitis virus in raw ruminant milk in Turkiye using real-time PCR.Archives of virology · 2026Article
- Development of an mRNA Vaccine for Tick-Borne Encephalitis: Selection of a Prototype Virus Strain.Vaccines · 2026Article
- Milk Modulates the Gastrointestinal Stability of Tick-Borne Encephalitis Virus: Implications for Alimentary Transmission.Journal of medical virology · 2026Article
- Tick-Borne Encephalitis in the 21Le infezioni in medicina · 2026Review
- Tick-Borne Viruses: Transmission and Surveillance.Viruses · 2025Article
- Meteorological and environmental factors associated with the exposure to tick-borne encephalitis virus (TBEV) in cattle, north-eastern France, 2018-2019.Veterinary research · 2025Article
- Seroprevalence of West Nile, Usutu and tick-borne encephalitis viruses in equids from south-western France in 2023.Veterinary research · 2025Article
- A Retrospective Sero-Surveillance Study for Antibodies Against Tick-Borne Encephalitis Virus in Norway.Viruses · 2025Article
- An autochthonous case of severeIDCases · 2025Article
- Tick-borne encephalitis virus subtypes: mono- and mixed infection in specific and non-specific ticks.Frontiers in cellular and infection microbiology · 2025Article
- Evaluation of Extraction Methods to Detect Noroviruses in Ready-to-Eat Raw Milk Minas Artisanal Cheese.Food and environmental virology · 2024Article
- Exposure of cattle to tick-borne encephalitis virus in the historical endemic zone in north-eastern France.BMC veterinary research · 2024Article
- Analysis of the zoonotic tick-borne encephalitis virus (TBEV) in raw milk and dairy products in mountain pastures of the Lombardy region, Italy.Frontiers in microbiology · 2024Article
- Seroprevalence of tick-borne encephalitis virus and vaccination coverage of tick-borne encephalitis, Sweden, 2018 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
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Authors and funding
28 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tick-borne encephalitis virus' (TBEV) geographic range and the human incidence are increasing throughout Europe, putting a number of non-endemic regions and countries at risk of outbreaks. In spring 2020, there was an outbreak of tick-born encephalitis (TBE) in Ain, Eastern France, where the virus had never been detected before. All patients but one had consumed traditional unpasteurised raw goat cheese from a local producer. We conducted an investigation in the suspected farm using an integrative One Health approach. Our methodology included (i) the detection of virus in cheese and milk products, (ii) serological testing of all animals in the suspected farm and surrounding farms, (iii) an analysis of the landscape and localisation of wooded area, (iv) the capture of questing ticks and small mammals for virus detection and estimating enzootic hazard, and (v) virus isolation and genome sequencing. This approach allowed us to confirm the alimentary origin of the TBE outbreak and witness in real-time the seroconversion of recently exposed individuals and excretion of virus in goat milk. In addition, we identified a wooded focus area where and around which there is a risk of TBEV exposure. We provide the first TBEV isolate responsible for the first alimentary-transmitted TBE in France, obtained its full-length genome sequence, and found that it belongs to the European subtype of TBEV. TBEV is now a notifiable human disease in France, which should facilitate surveillance of its incidence and distribution throughout France.
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