ArticleAnnals of gastroenterology
The association of weight gain with nonalcoholic fatty liver disease and fibrosis detected by FibroScan in the United States.
Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Risk Factors Related to the Development of Nonalcoholic Fatty Liver: A Systematic Review.Canadian journal of gastroenterology & hepatology · 2025Pooled it
- Prevalence and Risk Factors of Hepatic Steatosis in Kidney Transplant Recipients.Annals of transplantation · 2026Article
- Impact of Change, Fluctuation, or Variability in Weight on the Risk of Nonalcoholic Fatty Liver Disease in General Population: A Systematic Review and Meta-Analysis.Health science reports · 2025Article
- Impact of Weight Loss on Metabolic Dysfunction Associated Steatohepatitis and Hepatic Fibrosis.Current diabetes reports · 2025Review
- Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease Area.Diagnostics (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Studies have reported the association between weight gain and nonalcoholic fatty liver disease (NAFLD) in the Asian population. We investigated the association between weight gain, NAFLD and significant fibrosis measured by transient elastography in a representative Unites States sample. Methods: A cross-sectional study of 2849 participants was performed using the 2017-2018 National Health and Nutrition Examination Survey. We defined NAFLD by controlled attenuation parameter (CAP) scores and significant fibrosis (≥F2) by liver stiffness measurements using transient elastography, in the absence of other causes of chronic liver disease. A questionnaire that assessed weight change over 1 (short term) and 10 years (long term) was utilized. Results: Age- and sex-adjusted odds ratios (OR) for NAFLD, comparing the third and fourth quartiles (weight-gain group) with the second quartile (weight-stable group, reference), were 1.61 (95% confidence interval [CI] 1.07-2.43) and 3.58 (95%CI 2.19-5.86), respectively. The association between weight gain and NAFLD remained significant after adjustment for demographic and metabolic risk factors (OR 1.87, 95%CI 1.19-2.95 for CAP score ≥263 dB/m; OR 2.23, 95%CI 1.48-3.35 for CAP ≥285 dB/m). In terms of significant fibrosis, multivariate-adjusted OR for significant fibrosis were 1.99 (95%CI 1.05-3.79 for the third quartile) and 3.12 (95%CI 1.46-6.65 for the fourth quartile), respectively. A statistically significant association between weight gain over 1 year and NAFLD was noted, whereas no such association was found between weight gain and significant fibrosis. Conclusion: Weight gain over 10 years was associated with increased odds of NAFLD and significant fibrosis.
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Registered trials
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