ArticleFrontiers in psychiatry2022
Interoception Dysfunction Contributes to the Negative Emotional Bias in Major Depressive Disorder.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Heartbeat-Evoked Responses in M/EEG: A Systematic Review of Methods With Suggestions for Analysis and Reporting.Psychophysiology · 2026Pooled it
- The Qur'anic heart and converging evidence from contemporary cardiac science: From qalb to cardioception.Journal of Taibah University Medical Sciences · 2026Review
- Heartbeat-evoked potentials reveal interoceptive dysfunction in clinical disorders: Experimental frameworks and promising applications.Psychological medicine · 2026Review
- Digital phenotyping for assessment and prediction of interoception, chronic stress, and self-regulation in adults: a scoping review.Frontiers in digital health · 2026Review
- Interoceptive NeuroEmpowerment Scale: a trauma-informed measure of adaptive state ownership.Frontiers in human neuroscience · 2026Article
- Heart-Brain Axis Dysregulation in Depression: Mechanisms and Implications for Neuromodulation.Neuropsychiatric disease and treatment · 2026Review
- Major depressive disorder is characterized by differential theta and alpha patterns during working memory updating.BMC psychiatry · 2025Article
- Reduced Trust in Bodily Sensations Predicts Suicidal Ideation in Hospitalized Patients With Major Depression: An Observational Study.Suicide & life-threatening behavior · 2025Observational
- Increased Modulation of Low-Frequency Cardiac Rhythms on Resting-State Left Insula Alpha Oscillations in Major Depressive Disorder: Evidence from a Magnetoencephalography Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Sex Differences in the Association between Social Support and Major Depression: A Mediation Analysis with Interoception Mediator.Alpha psychiatry · 2025Article
- Neurobiological and neuropsychological disturbance in EDS.Frontiers in neurology · 2025Review
- Allostatic Interoceptive Overload Across Psychiatric and Neurological Conditions.Biological psychiatry · 2025Review
- Interoception mediates the association between social support and sociability in patients with major depressive disorder.World journal of psychiatry · 2024Article
- Unveiling the interoception impairment in various major depressive disorder stages.CNS neuroscience & therapeutics · 2024Article
- Brain-heart interaction disruption in major depressive disorder: disturbed rhythm modulation of the cardiac cycle on brain transient theta bursts.European archives of psychiatry and clinical neuroscience · 2024Article
- Increased insula response to interoceptive attention following mindfulness training is associated with increased body trusting among patients with depression.Psychiatry research. Neuroimaging · 2022Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous research studies have demonstrated that impaired interoception is involved in emotional information processing in major depressive disorder (MDD). Heartbeat-evoked potential (HEP) amplitudes, an index for interoception, could be manipulated by emotional faces in healthy people. Considering negative emotional bias is the core characteristic in MDD, we hypothesized that interoception dysfunction was associated with the negative emotional bias in MDD. Methods: An electroencephalogram (EEG) study under an emotional faces task was applied to explore the relationship between interoception and emotional bias. HEPs before emotional faces stimuli were used to predict the late positive potential (LPP) amplitudes and it worked as an index of emotional bias. Twenty-seven patients with MDD and 27 healthy controls (HCs) participated in this study. Source analysis gave an auxiliary description for results in sensory level. Results: Major depressive disorders (MDDs) had poor performance in the heartbeat count task (HCT) and attenuate HEP average amplitudes (455-550 ms). Compared with HCs, cluster-based permutation Conclusion: Mediated by ACC and insula, interoception dysfunction contributes to the negative emotional bias of MDD, highlighting the importance of interoception in the disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.