ArticleRSC advances2021
First total synthesis of chromanone A, preparation of related compounds and evaluation of their antifungal activity against
Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Eco-Friendly and Efficient Synthesis of 2-Hydroxy-3-Hydrazono-Chromones ThroughMolecules (Basel, Switzerland) · 2025Article
- The Synthesis, Fungicidal Activity, and in Silico Study of Alkoxy Analogues of Natural Precocenes I, II, and III.Molecules (Basel, Switzerland) · 2022Article
- Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds.Molecules (Basel, Switzerland) · 2022Article
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Authors and funding
6 authors.
Funding
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Abstract
A straightforward and convenient approach for the first total syntheses of chromanone A and a related 7-OMe substituted natural product is reported. These unique C-3 substituted 2-hydroxymethyl chromones were recently isolated as fungal metabolites. Chromanone A was synthesized in 25.3% overall yield from the readily available pyrocatechol, whereas the second natural product was prepared in 39.7% global yield. A small library of chromones, including both natural products and some of their synthetic heterocyclic precursors, was evaluated against
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