Evidence map›Paper›PMID 35479148›Full record

ArticleRSC advances2021

A frogspawn-like Ag@C core-shell structure for an ultrasensitive label-free electrochemical immunosensing of carcinoembryonic antigen in blood plasma.

Mengkui Ding, Ling Zha, Hui Wang, Jinyao Liu, Peiwu Chen, Yuefeng Zhao, Lan Jiang, Yuhao Li, Ruizhuo Ouyang, Yuqing Miao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mengkui DingInstitute of Bismuth Science, University of Shanghai for Science and Technology Shanghai 200093 P. R. China ouyangrz@usst.edu.cn.
Ling ZhaDepartment of Laboratory Diagnosis, Changhai Hospital, Naval Medical University Shanghai 20043 P. R. China.
Hui WangInstitute of Bismuth Science, University of Shanghai for Science and Technology Shanghai 200093 P. R. China ouyangrz@usst.edu.cn.
Jinyao LiuInstitute of Bismuth Science, University of Shanghai for Science and Technology Shanghai 200093 P. R. China ouyangrz@usst.edu.cn.
Peiwu ChenInstitute of Bismuth Science, University of Shanghai for Science and Technology Shanghai 200093 P. R. China ouyangrz@usst.edu.cn.
Yuefeng ZhaoInstitute of Bismuth Science, University of Shanghai for Science and Technology Shanghai 200093 P. R. China ouyangrz@usst.edu.cn.
Lan JiangInstitute of Bismuth Science, University of Shanghai for Science and Technology Shanghai 200093 P. R. China ouyangrz@usst.edu.cn.
Yuhao LiInstitute of Bismuth Science, University of Shanghai for Science and Technology Shanghai 200093 P. R. China ouyangrz@usst.edu.cn.
Ruizhuo OuyangInstitute of Bismuth Science, University of Shanghai for Science and Technology Shanghai 200093 P. R. China ouyangrz@usst.edu.cn.ORCID https://orcid.org/0000-0003-0562-7569
Yuqing MiaoInstitute of Bismuth Science, University of Shanghai for Science and Technology Shanghai 200093 P. R. China ouyangrz@usst.edu.cn.
University of Shanghai for Science and Technology · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A three-dimensional (3D) frogspawn-like structure was achieved by simply coating nano-carbon outside silver nanospheres (Ag@C NFS) and used as a probe to capture the anti-carcinoembryonic antigen for the electrochemical immunosensing of carcinoembryonic antigen (CEA), a typical biomarker of several diseases such as gastric cancer, intestinal cancer and colon cancer. Moreover, Ag@C nanocables (Ag@C NCs) were aslo synthesized. By comparison, the globular 3D frogspawn-like structure endowed Ag@C NFS with a larger surface area, which is preferred to improve the capability of loading antibodies, higher water solubility, better biocompatibility and improved electrical conductivity, which was likely attributed to the synergistic effects of Ag and crystalline graphite carbon and the different structure with more hydroxyl groups exposed. Therefore, the resultant Ag@C NFS was used as an electrochemical immunosensing platform to fabricate a label-free immunosensor for the analysis of CEA, which showed an excellent immunosensing performance with a wide linear CEA detection range from 0.0001 ng mL

Identifiers

PMID35479148
PMCPMC9030918
OpenAlexW3158309928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.