Evidence map›Paper›PMID 35478957›Full record

ArticleFrontiers in cell and developmental biology2022

A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility.

Eriklis Nogueira, Filip Tirpák, Lauren E Hamilton, Michal Zigo, Karl Kerns, Miriam Sutovsky, JaeWoo Kim, Dietrich Volkmann, Luca Jovine, Jeremy F Taylor and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Genome-wide association analysis highlights genomic regions and genes potentially associated with anestrus in crossbred gilts.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  2. Mechanisms of Development of Sperm Defects.Advances in anatomy, embryology, and cell biology · 2025
    Review
  3. Bull Sperm Abnormalities in Practice.Advances in anatomy, embryology, and cell biology · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. QTLs and Candidate Genes Associated with Semen Traits in Merino Sheep.Animals : an open access journal from MDPI · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 4 countries.

Eriklis NogueiraDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
Filip TirpákDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
Lauren E HamiltonDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
Michal ZigoDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
Karl KernsDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
Miriam SutovskyDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
JaeWoo KimDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
Dietrich VolkmannTheriogenology Laboratory, School of Veterinary Medicine, University of Missouri, Columbia, MO, United States.
Luca JovineDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Jeremy F TaylorDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
Robert D SchnabelDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
Peter SutovskyDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
University of Missouri · USKarolinska Institutet · SE

Funding

Linking Fertility-Associated Gene Polymorphisms to Aberrant Sperm PhenotypesR01HD084353 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI SUTOVSKY, PETER SUTOVSKY · 2016 to 2020
$1.7M
NICHD NIH HHS R01 HD084353
6 · The paper itself

Abstract

This study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in

Indexed as

acrosomal biogenesisbovinefertilityfertilizationknobbed acrosomeSNPspermatozoaspermiogenesis

Identifiers

PMID35478957
PMCPMC9037033
OpenAlexW4223548977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.