ArticleFrontiers in aging neuroscience2022
Inhibitory Control of Saccadic Eye Movements and Cognitive Impairment in Mild Cognitive Impairment.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Eyes on dementia: an overview of the interplay between eye movements and cognitive decline.Journal of medicine and life · 2023Pooled it
- Utility of Tablet-Based Eye Tracking for Early Screening of Poststroke Cognitive Impairment: Diagnostic Cohort Study.JMIR mHealth and uHealth · 2026Article
- Evaluating digital cognitive tests for clinical use in Alzheimer's disease: A novel framework and scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Machine Learning Integration of Eye-Tracking and Cognitive Screening for Detecting Cognitive Impairment.Journal of eye movement research · 2026Article
- Effects of an Eye-Tracking Digital Serious Game on Cognitive Function in Mild Cognitive Impairment: Pilot Intervention Study.JMIR formative research · 2026Article
- Advances in ocular motor and pupil biomarkers for neurological disorders.Brain communications · 2026Review
- Combining Cognitive and Sensorimotor Assessments to Facilitate Detection of Age-Related Cognitive Decline.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- An accessible and efficient mobile eye-tracking application for community-based cognitive impairment screening in China.Alzheimer's research & therapy · 2025Article
- Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes.Frontiers in aging neuroscience · 2025Article
- The correlation between muscle strength, inhibitory function, and cognitive function in older adults with cognitive impairment: evidence from resting-state electroencephalography.Frontiers in aging neuroscience · 2025Article
- Prefrontal intra-individual ERP variability and its asymmetry: exploring its biomarker potential in mild cognitive impairment.Alzheimer's research & therapy · 2024Article
- Research Progress of Eye Movement Analyses and its Detection Algorithms in Alzheimer's Disease.Current Alzheimer research · 2024Review
- Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
- Feasibility of self-reported health related quality of life assessment with older people in residential care: insights from the application of eye tracking technology.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Error monitoring in amnestic mild cognitive impairment: Cognitive correlates and relationship to measures of everyday function.Neuropsychology · 2023Article
- Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review.Frontiers in psychology · 2023Review
- Eye movement changes as an indicator of mild cognitive impairment.Frontiers in neuroscience · 2023Article
- Prefrontal event-related potential markers in association with mild cognitive impairment.Frontiers in aging neuroscience · 2023Article
- Acetylcholine deficit causes dysfunctional inhibitory control in an aging-dependent manner.Scientific reports · 2022Article
- Task-evoked pupillary responses as potential biomarkers of mild cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Mild cognitive impairment (MCI) may occur due to several forms of neurodegenerative diseases and non-degenerative conditions and is associated with cognitive impairment that does not affect everyday activities. For a timely diagnosis of MCI to prevent progression to dementia, a screening tool of fast, low-cost and easy access is needed. Recent research on eye movement hints it a potential application for the MCI screening. However, the precise extent of cognitive function decline and eye-movement control alterations in patients with MCI is still unclear. Objective: This study examined executive control deficits and saccade behavioral changes in patients with MCI using comprehensive neuropsychological assessment and interleaved saccade paradigms. Methods: Patients with MCI ( Results: The findings revealed significantly longer latency in patients with MCI than in HC during the PS task. Additionally, patients with MCI had a lower proportion of correct responses and a marked increase in inhibition errors for both PS/AS and Go/No-go tasks. Furthermore, when patients with MCI made errors, they failed to self-correct many of these inhibition errors. In addition to the increase in inhibition errors and uncorrected inhibition errors, patients with MCI demonstrated a trend toward increased correction latencies. We also showed a relationship between neuropsychological scores and correct and error saccade responses. Conclusion: Our results demonstrate that, similar to patients with Alzheimer's dementia (AD), patients with MCI generate a high proportion of erroneous saccades toward the prepotent target and fail to self-correct many of these errors, which is consistent with an impairment of inhibitory control and error monitoring. Significance: The interleaved PS/AS and Go/No-go paradigms are sensitive and objective at detecting subtle cognitive deficits and saccade changes in MCI, indicating that these saccadic eye movement paradigms have clinical potential as a screening tool for MCI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.