Evidence map›Paper›PMID 35478645›Full record

ArticleRSC advances2021

Exploration of stilbenoid trimers as potential inhibitors of sirtuin1 enzyme using a molecular docking and molecular dynamics simulation approach.

Muhammad Ikhlas Abdjan, Nanik Siti Aminah, Imam Siswanto, Alfinda Novi Kristanti, Yoshiaki Takaya, Muhammad Iqbal Choudhary

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Muhammad Ikhlas AbdjanDepartement of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia nanik-s-a@fst.unair.ac.id.
Nanik Siti AminahDepartement of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia nanik-s-a@fst.unair.ac.id.ORCID https://orcid.org/0000-0002-2767-6006
Imam SiswantoDepartement of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia nanik-s-a@fst.unair.ac.id.
Alfinda Novi KristantiDepartement of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia nanik-s-a@fst.unair.ac.id.
Yoshiaki TakayaFaculty of Pharmacy, Meijo University 150 Yagotoyama, Tempaku Nagoya 468-8503 Japan.
Muhammad Iqbal ChoudharyH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi Karachi-75270 Pakistan.ORCID https://orcid.org/0000-0001-5356-3585
University of Surabaya · IDAirlangga University · IDUniversity of Karachi · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A combination of molecular docking and molecular dynamics simulation (250 ns) has been carried out to study the interaction of stilbenoid trimer compounds with the SIRT1 enzyme as the target protein. SIRT1 expression regulates cellular stress responses that lead to the development of cancer. Redocking showed a good native ligand pose with an RMSD value of 1.40 Å at the receptor active site's coordinates. The molecular docking score uses a grid score functional (kcal mol

Identifiers

PMID35478645
PMCPMC9033617
OpenAlexW3167623327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.