ReviewJournal of cardiovascular electrophysiology2022
The development of the extravascular defibrillator with substernal lead placement: A new Frontier for device-based treatment of sudden cardiac arrest.
Review in Journal of cardiovascular electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Safety and Efficacy of the Extravascular Implantable Cardioverter-Defibrillator (EV-ICD) in Japanese Patients: Final Results From the EV ICD Japan Study.Circulation reports · 2026Article
- Mediastinal Air Entrapment During Extravascular ICD Implantation: A Preventable Cause of Elevated Shock Impedance.Journal of cardiovascular electrophysiology · 2026Article
- A Contemporary Review of Subcutaneous and Extravascular Implantable Cardiac Defibrillators.The Journal of innovations in cardiac rhythm management · 2026Review
- Implantation of an extravascular defibrillator with a preexisting endocardial dual-chamber defibrillator: When 2 defibrillators share 1 heart.HeartRhythm case reports · 2026Article
- Safety and efficacy of an extravascular implantable cardioverter-defibrillator in a child: A case report.HeartRhythm case reports · 2026Article
- Successful termination of ventricular tachycardia by an extravascular implantable cardioverter-defibrillator in a young patient with arrhythmogenic right ventricular cardiomyopathy.HeartRhythm case reports · 2026Article
- Review
- Concomitant use of the novel extravascular implantable cardioverter-defibrillator with an epicardial pacemaker.HeartRhythm case reports · 2025Article
- Implantation of an extravascular defibrillator during coronary artery bypass surgery.HeartRhythm case reports · 2025Article
- Extravascular Implantable Cardioverter-Defibrillators: A Systematic Review of Emerging Evidence.Cureus · 2025Review
- VITALS: an implantable sensor network for postoperative cardiac monitoring in heart failure patients.npj biomedical innovations · 2025Article
- Extravascular defibrillator implant in a patient with Poland syndrome.HeartRhythm case reports · 2025Article
- Design of a post-market registry for the extravascular implantable cardioverter-defibrillator: The Enlighten Study.Heart rhythm O2 · 2025Article
- [Practical guidance for the implantation of non-transvenous ICD systems].Herzschrittmachertherapie & Elektrophysiologie · 2024Article
- Article
- The substernal implantable cardioverter-defibrillator: First experience combining an extravascular-implantable cardioverter-defibrillator with a dual-chamber transvenous pacemaker.HeartRhythm case reports · 2024Article
- Ultrasound utilization for implantation of cardiac implantable electronic devices.Wiener klinische Wochenschrift · 2023Review
- Evolution of extravascular implantable cardioverter-defibrillator therapy for ventricular arrhythmias.Heart rhythm O2 · 2023Review
- Emerging Concepts on Infection of Novel Cardiac Implantable Devices.Reviews in cardiovascular medicine · 2022Review
- The development of the extravascular defibrillator with substernal lead placement: A new Frontier for device-based treatment of sudden cardiac arrest.Journal of cardiovascular electrophysiology · 2022Review
Corrections and comments
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Authors and funding
13 authors at 12 institutions in 8 countries.
Funding
Abstract
introductionThe extravascular implantable cardioverter-defibrillato (EV ICD) system with substernal lead placement is a novel nontransvenous alternative to current commercially available ICD systems. The EV ICD provides defibrillation and pacing therapies without the potential long-term complications of endovascular lead placement but requires a new procedure for implantation with a safety profile under evaluation.
methodsThis paper summarizes the development of the EV ICD, including the preclinical and clinical evaluations that have contributed to the system and procedural refinements to date.
resultsExtensive preclinical research evaluations and four human clinical studies with >140 combined acute and chronic implants have enabled the development and refinement of the EV ICD system, currently in worldwide pivotal study.
conclusionThe EV ICD may represent a clinically valuable solution in protecting patients from sudden cardiac death while avoiding the long-term consequences of transvenous hardware. The EV ICD offers advantages over transvenous and subcutaneous systems by avoiding placement in the heart and vasculature; relative to subcutaneous systems, EV ICD requires less energy for defibrillation, enabling a smaller device, and provides pacing features such as antitachycardia and asystole pacing in a single system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.