ArticleScientific reports2022
Pyrethroid-piperonyl butoxide (PBO) nets reduce the efficacy of indoor residual spraying with pirimiphos-methyl against pyrethroid-resistant malaria vectors.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 43 citations in OpenAlex.
- Community evaluation of VECTRON™ T500, a broflanilide insecticide, for indoor residual spraying for malaria vector control in central Benin; a two arm non-inferiority cluster randomised trial.Scientific reports · 2023Trial
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- Functional analysis of down-regulated CYP6AE gene clusters involved in the insecticidal mechanism of lycorine against Spodoptera litura.Pest management science · 2026Article
- A multi-country non-inferiority experimental hut evaluation of DuraNetMalaria journal · 2026Article
- Pepper Constituents Enhance the Toxicity and Neurophysiological Effects of Natural Pyrethrins in Insects.Insects · 2026Article
- Experimental hut evaluation of mosquito shield, a transfluthrin spatial emanator, for control of wild pyrethroid resistant malaria vectors in Benin.Scientific reports · 2026Article
- Targeting elongation factor 2 inFrontiers in insect science · 2026Review
- First report of widespread kdr-L995F pyrethroid-resistant An. arabiensis and Temporal trends of pyrethroid resistance in urban Ilorin, Kwara State, Nigeria.BMC infectious diseases · 2025Article
- Efficacy of Vector Guard®, a mosaic alpha-cypermethrin and piperonyl butoxide-treated net, for the control of pyrethroid-resistant malaria vectors: a non-inferiority experimental hut evaluation in Benin.Parasites & vectors · 2025Article
- Repellency and toxicity of long-lasting insecticide-treated bed nets (LLINs) to bed bugs.PloS one · 2025Article
- Article
- Pyrethroid-resistant malaria vector Anopheles gambiae restored susceptibility after pre-exposure to piperonyl-butoxide: results from country-wide insecticide resistance monitoring in Tanzania, 2023.Malaria journal · 2024Article
- The experimental hut efficacy of next-generation insecticide-treated nets against pyrethroid-resistant malaria vectors after 12, 24 and 36 months of household use in Benin.Malaria journal · 2024Article
- Efficacy of PermaNetMalaria journal · 2024Article
- Determinants of malaria spread among under-five children in Nigeria: results from a 2021 Nigerian malaria indicator cross-sectional survey.BMC pediatrics · 2024Article
- Pyrethroid resistance and gene expression profile of a new resistantWellcome open research · 2024Article
- Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers.Scientific reports · 2023Article
- PermaNet Dual, a new deltamethrin-chlorfenapyr mixture net, shows improved efficacy against pyrethroid-resistant Anopheles gambiae sensu lato in southern Benin.Scientific reports · 2023Article
- Can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (PBO) nets?Malaria journal · 2023Article
- Insecticides for Mosquito Control: Improving and Validating Methods to Strengthen the Evidence Base.Insects · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pirimiphos-methyl is a pro-insecticide requiring activation by mosquito cytochrome P450 enzymes to induce toxicity while PBO blocks activation of these enzymes in pyrethroid-resistant vector mosquitoes. PBO may thus antagonise the toxicity of pirimiphos-methyl IRS when combined with pyrethroid-PBO ITNs. The impact of combining Olyset Plus and PermaNet 3.0 with Actellic 300CS IRS was evaluated against pyrethroid-resistant Anopheles gambiae s.l. in two parallel experimental hut trials in southern Benin. The vector population was resistant to pyrethroids and PBO pre-exposure partially restored deltamethrin toxicity but not permethrin. Mosquito mortality in experimental huts was significantly improved in the combinations of bendiocarb IRS with pyrethroid-PBO ITNs (33-38%) compared to bendiocarb IRS alone (14-16%, p < 0.001), demonstrating an additive effect. Conversely, mortality was significantly reduced in the combinations of pirimiphos-methyl IRS with pyrethroid-PBO ITNs (55-59%) compared to pirimiphos-methyl IRS alone (77-78%, p < 0.001), demonstrating evidence of an antagonistic effect when both interventions are applied in the same household. Mosquito mortality in the combination was significantly higher compared to the pyrethroid-PBO ITNs alone (55-59% vs. 22-26% p < 0.001) showing potential of pirimiphos-methyl IRS to enhance vector control when deployed to complement pyrethroid-PBO ITNs in an area where PBO fails to fully restore susceptibility to pyrethroids.
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