Evidence map›Paper›PMID 35478197›Full record

ArticlePhytotherapy research : PTR2022

Cardiovascular benefits of Eruca sativa mill. Defatted seed meal extract: Potential role of hydrogen sulfide.

Lara Testai, Eleonora Pagnotta, Eugenia Piragine, Lorenzo Flori, Valentina Citi, Alma Martelli, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Roberto Matteo, Serafino Suriano and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Phytotherapy research : PTR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Freeze-Dried Extracts ofPreventive nutrition and food science · 2026
    Article
  5. Naturally Occurring HHandbook of experimental pharmacology · 2026
    Review
  6. Evolution of Secondary Metabolites inFoods (Basel, Switzerland) · 2025
    Article
  7. Biosynthesized Gold Nanoparticles fromAntibiotics (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. The Phytochemical Screening and Biological Properties ofMolecules (Basel, Switzerland) · 2023
    Article
  13. Plants and Mushrooms as Possible New Sources of HInternational journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. The Efficacy ofNutrients · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Lara TestaiDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID 0000-0003-2431-6248
Eleonora PagnottaCREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, Bologna, Italy.
Eugenia PiragineDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Lorenzo FloriDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Valentina CitiDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Alma MartelliDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID 0000-0002-2090-7107
Lorenzo Di Cesare MannelliDepartment of Neuroscience, Psychology, Drug Research and Child Health-Neurofarba- Pharmacology and Toxicology Section, University of Florence, Florence, Italy.ORCID 0000-0001-8374-4432
Carla GhelardiniDepartment of Neuroscience, Psychology, Drug Research and Child Health-Neurofarba- Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Roberto MatteoCREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, Bologna, Italy.
Serafino SurianoCREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, Foggia, Italy.
Antonio TroccoliCREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, Foggia, Italy.
Nicola PecchioniCREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, Foggia, Italy.
Vincenzo CalderoneDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID 0000-0002-1441-5421
University of Pisa · ITCereal Research Centre · ITUniversity of Florence · IT

Funding

Botanicals in the Treatment of Ageing-Related Cardiovascular Diseases PRA2017_26"Contratto per l'affidamento del servizio di consulenza farmacologica per la caratterizzazione cinetico-chimica del rilascio di acido solfidrico (H2S) da farmaci e molecole di origine naturale in soluzione, in vitro e in vivo e per la valutazione degli effetti di una modulazione della concentrazione di H2S in modelli in vitro e in vivo di patologie cardiovascolari e tumorali" funded by CREA Council for Agricultural Research and Economics, Italy Grant decree COMETA prot. n. 1741 of 05/07/2018Hydrogen Sulfide in the Vascular inflamm-Aging: role, therapeutic Opportunities and development of novel pharmacological tools for age-related cardiovascular diseases (SVAgO) PRIN 2017 _2017XP72RFMIUR-DAAD Joint Mobility Program (Prog. n. 32678, entitled: "RBC and EC NOS3 in exercise dependent cardioprotection: focus on mitochondria"). MIUR-DAAD Joint Mobility Program -Prog. n. 32678PON "Ricerca e Innovazione" 2014-2020-Azione II, by the COMETA research project "Colture autoctone mediterranee e loro valorizzazione con tecnologie avanzate di chimica verde" (Native Mediterranean crops and their enhancement with advanced green chemistry technologies) ARS01_00606
6 · The paper itself

Abstract

Eruca sativa Mill. is an edible plant belonging to the Brassicaceae botanical family with a long story as a medicinal material, mainly linked to the presence of glucoerucin. One of the main products of this glucosinolate is erucin, a biologicallly active isothiocyanate recently recognized as a hydrogen sulfide (H

Indexed as

BrassicaceaeCardiovascular SystemHydrogen SulfideAnimalsGlucosinolatesPlant ExtractsRatsSeedsGlucosinolatesHydrogen SulfidePlant Extractscardiovascular systemEruca sativa mill.erucinglucoerucinhydrogen sulfide

Identifiers

PMID35478197
PMCPMC9320972
OpenAlexW4225106363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.