Evidence map›Paper›PMID 35478176›Full record

ArticleJournal of neurointerventional surgery2023

The butterfly effect: improving brain cone-beam CT image artifacts for stroke assessment using a novel dual-axis trajectory.

Nicole Mariantonia Cancelliere, Eric Hummel, Fred van Nijnatten, Peter van de Haar, Paul Withagen, Marijke van Vlimmeren, Bertan Hallacoglu, Ronit Agid, Patrick Nicholson, Vitor Mendes Pereira

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurointerventional surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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  5. Current trends in antiplatelet strategies for emergent carotid stenting in acute tandem occlusions: a web-based, nationwide survey in the Italian neurovascular community.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nicole Mariantonia CancelliereDepartments of Neurosurgery and Medical Imaging, St Michael's Hospital, Toronto, Ontario, Canada nicole.cancelliere@unityhealth.to.ORCID http://orcid.org/0000-0002-8703-4304
Eric HummelImage Guided Therapy, Philips Healthcare, Best, Noord-Brabant, The Netherlands.
Fred van NijnattenImage Guided Therapy, Philips Healthcare, Best, Noord-Brabant, The Netherlands.ORCID http://orcid.org/0000-0001-6108-2255
Peter van de HaarImage Guided Therapy, Philips Healthcare, Best, Noord-Brabant, The Netherlands.
Paul WithagenImage Guided Therapy, Philips Healthcare, Best, Noord-Brabant, The Netherlands.
Marijke van VlimmerenImage Guided Therapy, Philips Healthcare, Best, Noord-Brabant, The Netherlands.
Bertan HallacogluImage Guided Therapy, Philips Healthcare, Best, Noord-Brabant, The Netherlands.
Ronit AgidJoint Department of Medical Imaging, Toronto Western Hospital, Toronto, Ontario, Canada.
Patrick NicholsonJoint Department of Medical Imaging, Toronto Western Hospital, Toronto, Ontario, Canada.
Vitor Mendes PereiraDepartments of Neurosurgery and Medical Imaging, St Michael's Hospital, Toronto, Ontario, Canada.
Philips (Netherlands) · NLSt. Michael's Hospital · CAToronto Western Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCone-beam computed tomography (CBCT) imaging of the brain can be performed in the angiography suite to support various neurovascular procedures. Relying on CBCT brain imaging solely, however, still lacks full diagnostic confidence due to the inferior image quality compared with CT and various imaging artifacts that persist even with modern CBCT.

objectiveTo perform a detailed evaluation of image artifact improvement using a new CBCT protocol which implements a novel dual-axis 'butterfly' trajectory.

methodsOur study included 94 scans from 47 patients who received CBCT imaging for assessment of either ischemia or hemorrhage during a neurovascular procedure. Both a traditional uni-axis 'circular' and novel dual-axis 'butterfly' protocol were performed on each patient (same-patient control). Each brain scan was divided into six regions and scored out of 3 based on six artifacts originating from various physics-based and patient-based sources.

resultsThe dual-axis trajectory produces CBCT images with significantly fewer image artifacts than the traditional circular scan (whole brain average artifact score, AS: 0.20 vs 0.33), with the greatest improvement in bone beam hardening (AS: 0.13 vs 0.78) and cone-beam artifacts (AS: 0.04 vs 0.55).

conclusionsRecent developments in CBCT imaging protocols have significantly improved image artifacts, which has improved diagnostic confidence for stroke and supports a direct-to-angiography suite transfer approach for patients with acute ischemic stroke.

Indexed as

ArtifactsIschemic StrokeAlgorithmsBrainCone-Beam Computed TomographyHumansImage Processing, Computer-AssistedPhantoms, ImagingAngiographyBrainCTStrokeTechnology

Identifiers

PMID35478176
PMCPMC9985729
OpenAlexW4225099280

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.