ArticleIn vivo (Athens, Greece)
Difficulty in Distinguishing Pulmonary Arterial Intimal Sarcoma from Pulmonary Thromboembolism Using FDG PET/CT.
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8 citing papers in PubMed, 10 citations in OpenAlex.
- Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report and literature review.Oncology letters · 2025Article
- Aortic intimal sarcoma with abdominal metastasis: case report and management approach.Frontiers in oncology · 2025Article
- The diagnostic value of [European radiology · 2024Article
- Primary mediastinal extraskeletal osteosarcoma onQuantitative imaging in medicine and surgery · 2024Article
- Comparison of pulmonary artery sarcoma and pulmonary thromboembolism according to clinical and computed tomography pulmonary angiography and magnetic resonance imaging characteristics: a single-center retrospective study.Quantitative imaging in medicine and surgery · 2024Article
- Early experience with pulmonary endarterectomy in Bulgaria-case series.Annals of translational medicine · 2023Article
- Problems and countermeasures for surgical resection of primary pulmonary artery intimal sarcoma.Translational cancer research · 2023Article
- Pulmonary thromboembolic disease or pulmonary artery intimal sarcoma: Case report and literature review.Oncology letters · 2022Article
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4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimPulmonary arterial intimal sarcoma (PAIS) is a rare malignant soft tissue tumor that is difficult to differentiate from pulmonary thromboembolism (PTE). Therefore, pre-operative diagnosis is often difficult. However, recent advances in fluorodeoxyglucose positron emission tomography (FDG-PET) have enabled the use of standardized uptake values (SUVs) for the differential diagnosis of PAIS from PTE, and the frequency of diagnosis of PAIS has increased. Here, we report a case of PAIS that was difficult to differentiate from PTE despite using FDG-PET. CASE REPORT: A 40-year-old woman presented with gradually worsening exertional dyspnea. Contrast-enhanced computed tomography (CT) revealed lesions with poor enhancement in the right lateral basal pulmonary artery. FDG-PET/CT did not reveal any tumor or thrombosis in other areas. Cytological evaluation using a right ventricular catheter did not lead to a definitive diagnosis. Because the patient did not respond to anticoagulation, we performed pulmonary artery endarterectomy. Pathological examination of the pulmonary artery tumor revealed a mucinous tumor with an edematous stroma and spindle-shaped tumor-cell proliferation, which confirmed the diagnosis of PAIS. However, FDG/PET demonstrated a low SUV of 3.4.
conclusionSome PAISs with low cellular densities and high mucous tissue proportions have SUVs similar to those in PTE. In patients with low FDG uptake, if PAIS is suspected based on other objective findings, additional exploration using highly invasive tests or surgical procedures specific to PAIS is warranted.
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