Evidence map›Paper›PMID 35478148›Full record

ArticleIn vivo (Athens, Greece)

Bisdemethoxycurcumin-mediated Attenuation of Apoptosis Prevents Gentamicin-induced Ototoxicity in Mouse Cochlear UB/OC-2 Cells.

Ting-Ya Kang, Chuan-Jen Hsu, Jia-Ni Lin, Chen-Chi Wu, Jen-Shu Wang, Hui-Yi Lin, Szu-Hui Yu, Rong-Shuan Wu, Yu-Hsuan Wen, Guo-Fang Tseng and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ting-Ya Kang *Department of Otolaryngology Head and Neck Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, R.O.C.
Chuan-Jen Hsu *Department of Otolaryngology Head and Neck Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, R.O.C.
Jia-Ni LinDepartment of Otolaryngology Head and Neck Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, R.O.C.
Chen-Chi WuDepartment of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan, R.O.C.
Jen-Shu WangDepartment of Chinese Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, R.O.C.
Hui-Yi LinSchool of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.
Szu-Hui YuDepartment of Music, Tainan University of Technology, Tainan, Taiwan, R.O.C.
Rong-Shuan WuDepartment of Economics, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.
Yu-Hsuan WenSchool of Medicine, Tzu Chi University, Hualien, Taiwan, R.O.C.
Guo-Fang TsengInstitute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, R.O.C.
Hung-Pin WuDepartment of Otolaryngology Head and Neck Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, R.O.C.; hungpin_wu@yahoo.com.tw.
Tzu Chi University · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimGentamicin has been widely prescribed since the last two decades despite its ototoxicity and nephrotoxicity. Bisdemethoxycurcumin (BDMC) is an affordable and safe curcuminoid with medicinal properties. We aimed to understand the effects of BDMC on the gentamicin-induced hair cell damage in mouse cochlear UB/OC-2 cells, in order to elucidate the therapeutic potential of BDMC against gentamicin-induced ototoxicity. MATERIALS AND

methodsWe quantified the cell membrane potential and examined the regulators and cascade proteins in the intrinsic pathway of hair cell apoptosis. Mouse cochlear UB/OC-2 cells were treated with BDMC before exposure to gentamicin. The effects of BDMC on hair cell viability, mitochondrial function, and apoptosis-related proteins were examined by flow cytometry, western blot, and fluorescent staining.

resultsOur results revealed that BDMC reversed gentamicin-mediated cycle arrest at the G

conclusionBDMC is a potential agent for reducing gentamicin-induced ototoxicity.

Indexed as

GentamicinsOtotoxicityAnimalsApoptosisDiarylheptanoidsMicebisdemethoxycurcuminDiarylheptanoidsGentamicinsapoptosisbisdemethoxycurcuminGentamicinmitochondrial functionototoxicityreactive oxygen species

Identifiers

PMID35478148
PMCPMC9087079
OpenAlexW4225083307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.