ArticleIn vivo (Athens, Greece)
Antihypertensive Drug Combinations Modify Cisplatin-induced Acute Kidney Injury.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Article
- Treatment-related mortality in head and neck cancer patients receiving chemotherapy and radiation: results of a meta-analysis of published trials.Therapeutic advances in medical oncology · 2025Article
- Evaluation of a new score associated with acute kidney injury in patients treated with cisplatin based EXTREME regimen.BMC cancer · 2024Article
- Association of Antiviral Drugs for the Treatment of COVID-19 With Acute Renal Failure.In vivo (Athens, Greece)Article
- Clinical Utility of Body Weight Monitoring During Cisplatin-based Chemotherapy.In vivo (Athens, Greece)Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimThere is limited evidence about the nephrotoxicity of calcium channel blockers (CCBs) and renin-angiotensin system (RAS) inhibitors with concomitant cisplatin (CDDP). We investigated whether combinations of antihypertensive drugs are associated with CDDP-related acute kidney injury (AKI) using the Japanese Adverse Drug Event Report database. PATIENTS AND
methodsWe analysed 544,864 reports in the database from 2004 to 2020. A reporting odds ratio (ROR) and confidence interval (CI) with adjustment for potential confounding factors was calculated for AKI for each drug and the combined use of the drugs and CDDP.
resultsCDDP, CCBs, and RAS inhibitors were all detected signals for AKI. The ROR in cases with concomitant use of CCBs, RAS inhibitors, and CDDP (adjusted ROR 7.28; 95% CI=5.56-9.54) was higher than that in cases with use of each drug.
conclusionAKI may require more attention when patients receiving CDDP take CCBs and RAS inhibitors together.
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