Evidence map›Paper›PMID 35478133›Full record

ArticleIn vivo (Athens, Greece)

Cost-effectiveness of Iterative Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Peritoneal Carcinomatosis.

James R M Colbourne, Sam T Alhayo, Beeshman Nandakumar, Shoma Barat, Winston Liauwi, David L Morris, Nayef A Alzahrani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James R M ColbourneDepartment of Surgery, University of New South Wales, St. George Hospital, Sydney, NSW, Australia; j.rmcolbourne@gmail.com.
Sam T AlhayoDepartment of Surgery, University of New South Wales, St. George Hospital, Sydney, NSW, Australia.
Beeshman NandakumarDepartment of Surgery, University of New South Wales, St. George Hospital, Sydney, NSW, Australia.
Shoma BaratDepartment of Surgery, University of New South Wales, St. George Hospital, Sydney, NSW, Australia.
Winston LiauwiCancer Care Centre, St. George Hospital, Sydney, NSW, Australia.
David L MorrisDepartment of Surgery, University of New South Wales, St. George Hospital, Sydney, NSW, Australia.
Nayef A AlzahraniDepartment of Surgery, University of New South Wales, St. George Hospital, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIterative cytoreduction (iCRS) and hyperthermic intraperitoneal chemotherapy is a treatment for recurrence of peritoneal carcinomatosis. There are considerable upfront costs for this approach for which the cost-effectiveness has not been evaluated. PATIENTS AND

methodsWe used a prospectively maintained database of patients having undergone primary and iterative cytoreduction at St. George Hospital between January 1, 2014, and December 31, 2017, which was linked with financial data. Cost effectiveness and survival outcomes were used to compare primary cytoreduction (pCRS) and iterative cytoreduction (iCRS) in addition to comparison with other treatment modalities.

resultsThe average cost per patient in Australian dollars was $69,295 ($14,691-$696,002) and the average cost per life-year was $15,842. There was no difference in cost-effectiveness between those who had undergone pCRS and those who had undergone iCRS. The overall survival was 52.5 months (95% confidence interval=49.7-55.2 months) with no difference in survival between pCRS and iCRS groups. The median length of hospital stay was significantly longer for patients in the pCRS treatment group (25.51 days) when compared to the iCRS treatment group (21.15 days, p=0.034).

conclusioniCRS is a cost-effective treatment in the management of recurrent peritoneal carcinomatosis.

Indexed as

Hyperthermia, InducedPeritoneal NeoplasmsAustraliaCost-Benefit AnalysisCytoreduction Surgical ProceduresHumansHyperthermic Intraperitoneal Chemotherapycost of illnesscytoreduction surgical proceduresGeneral surgeryperitoneal neoplasmssurgical oncology

Identifiers

PMID35478133
PMCPMC9087096

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.