Evidence map›Paper›PMID 35478113›Full record

ArticleIn vivo (Athens, Greece)

Association of miRNA-145 Single Nucleotide Polymorphisms in Abdominal Aortic Aneurysms.

Natasha Hasemaki, Nikolaos-Panagiotis Andreou, Evangelia Legaki, Athanasios Katsargyris, Maria Gazouli, Christos Klonaris

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Natasha HasemakiFirst Department of Surgery, Vascular Unit, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
Nikolaos-Panagiotis AndreouDepartment of Basic Medical Science, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Evangelia LegakiDepartment of Basic Medical Science, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Athanasios KatsargyrisFirst Department of Surgery, Vascular Unit, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
Maria GazouliDepartment of Basic Medical Science, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece; mgazouli@med.uoa.gr.
Christos KlonarisFirst Department of Surgery, Vascular Unit, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
National and Kapodistrian University of Athens · GRLaiko General Hospital of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimMicroRNAs (miRNAs) are non-coding RNA molecules that exert post-transcriptional gene expression regulation in response to cellular or environmental changes. Genetic variation affects their synthesis and cellular actions, and single nucleotide polymorphisms (SNPs) are one example of genetic variants studied in relation to various diseases. Literature indicates that the differentially expressed miRNA-145 in patients' serum is an essential biomarker for abdominal aortic aneurysm (AAA). However, the correlation between specific miR-145 genetic polymorphisms with AAA susceptibility is inadequately studied. MATERIALS AND

methodsEighty-seven AAA patients and 122 healthy controls were recruited. Peripheral blood samples were genotyped for miRNA-145 SNPs; rs55945735, rs73798217 and rs353291.

resultsThe GG genotype of the rs55945735 polymorphism (p=0.047) and the AG genotype of the rs353291 polymorphism (p=0.036) were overrepresented in AAA patients compared to healthy individuals, revealing an association with susceptibility to AAA development.

conclusionSNPs rs55945735 and rs353291 are associated with AAA susceptibility.

Indexed as

Aortic Aneurysm, AbdominalMicroRNAsGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideMicroRNAsMIRN145 microRNA, humanAbdominal aortic aneurysmsmiRNA-145miRNAsrs353291rs55945735rs73798217

Identifiers

PMID35478113
PMCPMC9087113
OpenAlexW4225106354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.