Evidence map›Paper›PMID 35478104›Full record

ArticleIn vivo (Athens, Greece)

Clinical Importance of Body Composition in Improving Bone Mineral Density of Femoral Neck After Denosumab Therapy in Patients With Rheumatoid Arthritis or Collagen Diseases.

Mai Nakano, Akimitsu Miyake, Ryuichiro Egashira, Mariko Takeuchi, Misaki Moriguchi, Satoko Tonari, Hitomi Saito, Hiroki Nishikawa, Kiyoshi Matsui, Keisuke Hagihara

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Mai NakanoDepartment of Advanced Hybrid Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Akimitsu Miyakedepartment of Medical Innovation, Osaka University Hospital, Suita, Japan.
Ryuichiro EgashiraDepartment of Advanced Hybrid Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Mariko TakeuchiDepartment of Advanced Hybrid Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Misaki MoriguchiDepartment of Advanced Hybrid Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Satoko TonariDepartment of Advanced Hybrid Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Hitomi SaitoDepartment of Advanced Hybrid Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Hiroki NishikawaThe Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Kiyoshi MatsuiDivision of Allergology and Rheumatology, Department of Diabetes Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Hyogo, Japan.
Keisuke HagiharaDepartment of Advanced Hybrid Medicine, Osaka University Graduate School of Medicine, Osaka, Japan; k.hagihara@kanpou.med.osaka-u.ac.jp.
Osaka University · JPHyogo University · JPOsaka University Hospital · JPOsaka University of Pharmaceutical Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimTo investigate factors associated with increased bone mineral density (BMD) of the neck of femur in rheumatoid arthritis or collagen diseases receiving denosumab, focusing on body composition calculated by bioelectrical impedance analysis (n=90, 78 females). PATIENTS AND

methodsWe defined Δfemur as BMD (12 months minus baseline), using dual-energy X-ray absorptiometry after denosumab therapy. Factors associated with Δfemur were retrospectively investigated.

resultsLow skeletal muscle index (SMI) was observed in 6 males and 32 females. There was a significant difference in phase angle (PhA) of the left leg (LL) between the Δfemur ≥0 (n=70) and Δfemur <0 (n=20) groups (p=0.040) but not in SMI (p=0.310). Multiple regression analysis indicated that PhA of LL was significantly related to Δfemur (p=0.0398).

conclusionPhA appears to be a clinically significant indicator of improvement of Δfemur in patients receiving denosumab.

Indexed as

Arthritis, RheumatoidCollagen DiseasesBody CompositionBone DensityDenosumabFemaleFemur NeckHumansMaleRetrospective StudiesDenosumabbody compositionbone mineral densityDenosumabneck of femurphase angle

Identifiers

PMID35478104
PMCPMC9087069
OpenAlexW4225082656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.