Evidence map›Paper›PMID 35478103›Full record

ArticleIn vivo (Athens, Greece)

Oral Misoprostol for the Induction of Labor: Comparison of Different Dosage Schemes With Respect to Maternal and Fetal Outcome in Patients Beyond 34 Weeks of Pregnancy.

Oana Ratiu, Dominik Ratiu, Peter Mallmann, Alexander DI Liberto, A Kubilay Ertan, Bernd Morgenstern, Michael R Mallmann, Sebastian Ludwig, Berthold Grüttner, Christian Eichler and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Oana Ratiu *Department of Gynecology and Obstetrics, Leverkusen Municipal Hospital, Leverkusen, Germany.
Dominik Ratiu *Department of Gynecology and Obstetrics, Leverkusen Municipal Hospital, Leverkusen, Germany.
Peter MallmannDepartment of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.
Alexander DI LibertoDepartment of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.
A Kubilay ErtanDepartment of Gynecology and Obstetrics, Leverkusen Municipal Hospital, Leverkusen, Germany.
Bernd MorgensternDepartment of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.
Michael R MallmannDepartment of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.
Sebastian LudwigDepartment of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.
Berthold GrüttnerDepartment of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.
Christian EichlerDepartment of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.
Fabinshy ThangarajahDepartment of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.
Elena GilmanDepartment of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.
Judith S AbelDepartment of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.
University Hospital Cologne · DEKlinikum Leverkusen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimLabor is induced in 1 out of 5 pregnancies. This is why we aimed to compare two different protocols of orally administered misoprostol for the induction of labor (IOL), with special regard to maternal and fetal outcome, delivery mode and duration. PATIENTS AND

methodsOne hundred and twenty four patients with a medical indication for IOL were divided into two groups: Group A (n=63), which initially received 50 μg misoprostol escalated to 100 and, subsequently, to 200 μg every 4 h with a daily maximum of 600μg, between 11/2007 and 01/2008; and Group B (n=61), which initially received 25 μg misoprostol followed by 100 μg every 4 h with a daily maximum of 300 μg, between 12/2009 and 04/2010.

resultsThe mean administration-delivery interval was significantly lower in Group A (19.0 h) compared to Group B (27.1 h, p<0.05). Overall caesarean section rate, average birth weight, APGAR score, umbilical cord pH and meconium-stained fluid rates were similar between both groups.

conclusionA higher dosage protocol of orally administered misoprostol significantly reduces the mean induction-delivery interval without increasing the risk for an adverse maternal or fetal outcome.

Indexed as

MisoprostolOxytocicsApgar ScoreCesarean SectionFemaleHumansInfant, NewbornLabor, InducedPregnancyMisoprostolOxytocicsinduction of laborOral misoprostol

Identifiers

PMID35478103
PMCPMC9087102
OpenAlexW4225097401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.