Evidence map›Paper›PMID 35478076›Full record

ArticleNano convergence2022

Peptide hydrogel with self-healing and redox-responsive properties.

Areetha D'Souza, Liam R Marshall, Jennifer Yoon, Alona Kulesha, Dona I U Edirisinghe, Siddarth Chandrasekaran, Parth Rathee, Rajeev Prabhakar, Olga V Makhlynets

Open access · diamondAbstract read
In one paragraph

Article in Nano convergence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  5. Review
  6. A Photochemically Active CuNanomaterials (Basel, Switzerland) · 2024
    Article
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Areetha D'SouzaDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA.
Liam R MarshallDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA.
Jennifer YoonDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA.
Alona KuleshaDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA.
Dona I U EdirisingheDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA.
Siddarth ChandrasekaranNational Biomedical Center for Advanced ESR Technology, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14583, USA.
Parth RatheeDepartment of Chemistry, University of Miami, Coral Gables, FL, 33146, USA.
Rajeev PrabhakarDepartment of Chemistry, University of Miami, Coral Gables, FL, 33146, USA.
Olga V MakhlynetsDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA. ovmakhly@syr.edu.ORCID http://orcid.org/0000-0002-2763-7891
Syracuse University · USUniversity of Miami · USCornell University · US

Funding

TR&D 4 for ACERT, 2017-2021 funding periodP41GM103521 · NIGMS · CORNELL UNIVERSITY · PI FREED, JACK H · 2012 to 2021
$11.7M
NIGMS NIH HHS P41 GM103521NIH HHS P41GM103521
6 · The paper itself

Abstract

We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.

Indexed as

Antimicrobial wound dressingCopper reductionHydrogelSelf-healing and redox-responsive properties

Identifiers

PMID35478076
PMCPMC9046503
OpenAlexW4225108587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.