Evidence map›Paper›PMID 35478045›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022

People living with HIV have low trabecular bone mineral density, high bone marrow adiposity, and poor trabecular bone microarchitecture at the proximal femur.

J Carballido-Gamio, M Posadzy, P-H Wu, K Kenny, I Saeed, T M Link, P C Tien, R Krug, G J Kazakia

Open access · greenAbstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Sex-specific bone architectural deficits among older adults living with HIV: a cross-sectional study from Zimbabwe.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  2. Article
  3. Review
  4. Simulated low-dose multi-detector computed tomography: spatial effects on surrogate parameters of bone strength at the proximal femur.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

J Carballido-GamioDepartment of Radiology, University of Colorado Anschutz Medical Campus, 12700 E 19th Ave, Mail Stop C278, Room 1208, Aurora, CO, 80045, USA. Julio.Carballido-Gamio@cuanschutz.edu.ORCID http://orcid.org/0000-0002-6593-7182
M PosadzyDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
P-H WuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
K KennyDepartment of Bioengineering, University of California, Berkeley, CA, USA.
I SaeedDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
T M LinkDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
P C TienDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
R KrugDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
G J KazakiaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USSan Francisco VA Medical Center · USUniversity of California, Berkeley · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wenhan Chang · 2019 to 2026
$7.1M
Bone quality and marrow adiposity in subjects with HIVR01AI125080 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAZAKIA, GALATEIA J, KRUG, ROLAND · 2017 to 2021
$2.7M
NIAID NIH HHS R01 AI125080NIAMS NIH HHS P30 AR075055NIAMS NIH HHS P30AR075055NIAMS NIH HHS P30 DK098722NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722
6 · The paper itself

Abstract

People living with HIV (PLWH) have increased risk of osteoporosis and fractures. We assessed the proximal femur of PLWH and age-matched seronegative controls using quantitative computed tomography and magnetic resonance imaging. Results suggest that the trabecular compartment is compromised at fracture-prone regions in the proximal femur of PLWH.

introductionPeople living with HIV (PLWH) have increased risk of osteoporosis and fractures. However, studies assessing the main determinants of bone strength in the proximal femur exclude this vulnerable population. We assessed the proximal femur of 40 PLWH and 26 age-matched seronegative controls using quantitative computed tomography and magnetic resonance imaging.

methodsWe examined cortical volumetric bone mineral density (Ct.vBMD), trabecular vBMD (Tb.vBMD), cortical thickness (Ct.Th), bone marrow adiposity (BMA), and trabecular number, separation, and bone volume fraction. Parametric comparisons between the two groups were made for the femoral head, femoral neck, trochanter, and total hip using linear regression adjusting for several covariates, including metrics of body composition. In addition, we investigated the associations of BMA with Tb.vBMD and trabecular microarchitecture with Spearman's rank partial correlations.

resultsPLWH had lower Tb.vBMD and deteriorated trabecular microarchitecture in the femoral neck, trochanter and total hip, and elevated BMA in the femoral head, femoral neck, and total hip. Ct.vBMD and Ct.Th were not significantly different between the two groups. BMA was significantly associated with lower Tb.vBMD and deteriorated trabecular microarchitecture in both groups albeit at different femoral regions.

conclusionsOur findings suggest that the trabecular, and not the cortical, compartment is compromised in the proximal femur of PLWH. The observed impairments in fracture-prone regions in PLWH indicate lower femoral strength and suggest higher fracture risk. The inverse associations of BMA with trabecular bone density and microarchitecture quality agree with findings at other anatomic sites and in other populations, suggesting that excess BMA possibly due to a switch from the osteoblast to the adipocyte lineage may be implicated in the pathogenesis of bone fragility at the femur in PLWH.

Indexed as

Bone DensityOsteoporosisAbsorptiometry, PhotonAdiposityBone MarrowCancellous BoneFemurHumansBone marrow fatBone microarchitectureBone mineral densityCortical bone thicknessHIV infection

Identifiers

PMID35478045
PMCPMC9509414
OpenAlexW4225087068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.