Evidence map›Paper›PMID 35478039›Full record

ArticleThe Journal of infectious diseases2022

Immunological Correlates of Prevention of the Onset of Seasonal H3N2 Influenza.

Moe Okuda, Yuko Sakai-Tagawa, Michiko Koga, Tomohiko Koibuchi, Tadashi Kikuchi, Eisuke Adachi, Lay Ahyoung Lim, Shinya Yamamoto, Hiroshi Yotsuyanagi, Kyota Negishi and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Moe OkudaDepartment of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Yuko Sakai-TagawaDepartment of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Michiko KogaDivision of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Tomohiko KoibuchiDepartment of Infectious Diseases and Applied Immunology, IMSUT Hospital of Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
Tadashi KikuchiDepartment of Infectious Diseases and Applied Immunology, IMSUT Hospital of Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
Eisuke AdachiDepartment of Infectious Diseases and Applied Immunology, IMSUT Hospital of Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
Lay Ahyoung LimDepartment of Infectious Diseases and Applied Immunology, IMSUT Hospital of Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
Shinya YamamotoDepartment of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Hiroshi YotsuyanagiDivision of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Kyota NegishiTokyo Health Cooperative Association, Nezu Clinic, Tokyo, Japan.
Daisuke JubishiTokyo Health Cooperative Association, Nezu Clinic, Tokyo, Japan.
Seiya YamayoshiDepartment of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7768-5157
Yoshihiro KawaokaDepartment of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Tokyo University of Science · JPUniversity of Tokyo Hospital · JPUniversity of Wisconsin–Madison · US

Funding

NIAID NIH HHS HHSN272201400008C
6 · The paper itself

Abstract

On influenza virus infection or vaccination, immune responses occur, including the production of antibodies with various functions that contribute to protection from seasonal influenza virus infection. In the current study, we attempted to identify the antibody functions that play a central role in preventing the onset of seasonal influenza by comparing the levels of several antibody titers for different antibody functions between 5 subclinically infected individuals and 16 patients infected with seasonal H3N2 virus. For antibody titers before influenza virus exposure, we found that the nAb titers and enzyme-linked immunosorbent assay titers against hemagglutinin and neuraminidase (NA) proteins in the subclinically infected individuals were significantly higher than those in the patients, whereas the NA inhibition titers and antibody-dependent cellular cytotoxicity activities did not significantly differ between subclinically infected individuals and infected patients. These results suggest that nAb and enzyme-linked immunosorbent assay titers against hemagglutinin and NA serve as correlates of symptomatic influenza infection.

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza, HumanInfluenza VaccinesAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusHemagglutininsHumansInfluenza A Virus, H3N2 SubtypeNeuraminidaseSeasonsAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusHemagglutininsInfluenza VaccinesNeuraminidaseantibody functions that inhibit influenza infectioncorrelates of protectionH3N2Influenza A virussubclinical infection

Identifiers

PMID35478039
PMCPMC10205605
OpenAlexW4225087469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.