Evidence map›Paper›PMID 35477996›Full record

ArticleCell research2022

Structural basis for pore blockade of human voltage-gated calcium channel Ca

Xia Yao, Shuai Gao, Nieng Yan

Abstract readLetter
In one paragraph

Article in Cell research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Evaluation of Aldosterone Suppression by Cinnarizine, a Putative Cav1.3 Inhibitor.The Journal of clinical endocrinology and metabolism · 2025
    Trial
  2. Voltage-sensing domains: structural and functional diversity.European biophysics journal : EBJ · 2026
    Review
  3. Article
  4. Article
  5. Nanoscale architecture and dynamics of CaJournal of molecular and cellular cardiology plus · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Deciphering CaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Calcium channels as pharmacological targets for cancer therapy.Clinical and experimental medicine · 2025
    Review
  13. Review
  14. Voltage sensors.Molecular pharmacology · 2025
    Review
  15. Review
  16. Review
  17. Autism-Linked Mutations in αPharmaceuticals (Basel, Switzerland) · 2024
    Article
  18. Review
  19. Article
  20. Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xia Yao *Department of Molecular Biology, Princeton University, Princeton, NJ, USA. xiayao@princeton.edu.ORCID 0000-0003-2406-268X
Shuai Gao *Department of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-8734-2489
Nieng YanDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA. nyan@princeton.edu.ORCID 0000-0003-4829-7416

Funding

Molecular mechanisms of action and resistance of sodium channel-targeting insectiR01GM057440 · NIGMS · MICHIGAN STATE UNIVERSITY · PI DONG, KE, HUGHSON, FREDERICK M · 1999 to 2023
$5.4M
Structural investigation of the gating and regulatory mechanism of voltage-gated Ca2+ channelsR01GM130762 · NIGMS · PRINCETON UNIVERSITY · PI YAN, NIENG · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM057440NIGMS NIH HHS R01 GM130762
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CinnarizineMotion SicknessCalciumCalcium Channels, L-TypeHumansCalciumCalcium Channels, L-TypeCinnarizine

Identifiers

PMID35477996
PMCPMC9525318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.