ArticleBiomechanics and modeling in mechanobiology2022
Contact guidance as a consequence of coupled morphological evolution and motility of adherent cells.
Article in Biomechanics and modeling in mechanobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A continuum mechanical model of cell motion driven by a biphasic traction stress.Journal of the Royal Society, Interface · 2024Article
- The influence of entropic crowding in cell monolayers.Biophysical journal · 2022Article
- Cell reorientation on a cyclically strained substrate.PNAS nexus · 2022Article
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3 authors.
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Abstract
Adherent cells seeded on substrates spread and evolve their morphology while simultaneously displaying motility. Phenomena such as contact guidance, viz. the alignment of cells on patterned substrates, are strongly linked to the coupling of morphological evolution with motility. Here, we employ a recently developed statistical thermodynamics framework for modelling the non-thermal fluctuating response of cells to probe this coupling. This thermodynamic framework is first extended via a Langevin style model to predict temporal responses of cells to unpatterned and patterned substrates. The Langevin model is then shown to not only predict the different experimentally observed temporal scales for morphological observables such as cell area and elongation but also the interplay of morphology with motility that ultimately leads to contact guidance.
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