ArticleNature2022
TLR7 gain-of-function genetic variation causes human lupus.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 348 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
348citing papers in PubMed, 2 pooled it
42.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
348 citing papers in PubMed, 2 syntheses or guidelines pooled it, 528 citations in OpenAlex.
- The extra X chromosome and autoimmune susceptibility in Klinefelter syndrome.The Journal of clinical endocrinology and metabolism · 2026Pooled it
- Emerging trends and focus of Toll-like receptors in kidney diseases: a 20-year bibliometric analysis.Frontiers in medicine · 2025Pooled it
- Enpatoran, a first-in-class, selective, orally administered toll-like receptor 7/8 inhibitor, in systemic and cutaneous lupus erythematosus: results from a randomised, placebo-controlled phase Ib study.Lupus science & medicine · 2025Trial
- Trial
- Nucleic acid sensing pathways in kidney disease development.Nature reviews. Nephrology · 2026Review
- Identification of a systemic lupus erythematosus disease signature in resting naive B cells.The Journal of clinical investigation · 2026Article
- Viral subversion of B-cell tolerance: mechanisms linking infection to autoimmunity.EMBO reports · 2026Review
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Disease modification in lupus nephritis: towards a pathophysiology-based treatment paradigm.Nature reviews. Nephrology · 2026Review
- A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.American journal of human genetics · 2026Article
- Advancements in Diagnosis and Care for Immune Dysregulation and Inborn Errors of Immunity in Pediatric Rheumatology: Our 50-Year Journey.Arthritis care & research · 2026Review
- The cellular landscape of druggable RNA-binding proteins.Nature reviews. Drug discovery · 2026Review
- The SLC15A4-TASL complex is essential for lupus development in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Integrating Patient-Centric Clinical Pharmacology and MID3 to Advance Biologic Development in Immune-Mediated Inflammatory Diseases.Clinical pharmacology and therapeutics · 2026Review
- From data to discovery: a unified framework for human immunology.Nature immunology · 2026Article
- Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease.Nature reviews. Immunology · 2026Review
- Evolution of self-reactive B cells: lessons from a lupus model.Biochemical Society transactions · 2026Review
- Microglial TLR7 contributes to traumatic brain injury-induced neuroinflammation in mice.Acta pharmacologica Sinica · 2026Article
- Innate immunity: current understandings and future perspectives.Signal transduction and targeted therapy · 2026Review
- SPEN Loss Drives Extrafollicular Diffuse Large B-cell Lymphoma with Female-Specific Lethality and Therapeutic Vulnerabilities.Cancer discovery · 2026Article
288 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
44 authors at 13 institutions in 5 countries.
Grant J BrownCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0002-9721-5539
Pablo F Cañete *Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Hao Wang *Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Arti MedhavyCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0003-2778-3650
Josiah BonesResearch School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0001-5419-9914
Jonathan A RocoCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Yuke HeChina Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University, Shanghai, China.ORCID http://orcid.org/0000-0002-6716-198X
Yuting QinChina Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Jean CappelloCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Julia I EllyardCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0001-6301-2533
Katharine BassettCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Qian ShenCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Gaetan BurgioCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Yaoyuan ZhangCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0002-0256-098X
Cynthia TurnbullCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Xiangpeng MengCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Phil WuCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Eun ChoCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0001-9039-9876
Lisa A MiosgeCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
T Daniel AndrewsCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0003-3922-6376
Matt A FieldCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0003-0788-6513
Denis TvorogovCentre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.
Angel F LopezCentre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.
Jeffrey J BabonDivision of Structural Biology, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-5408-6239
Cristina Aparicio LópezSección de Nefrología, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
África Gónzalez-MurilloUnidad de Terapias Avanzadas, Oncología, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.ORCID http://orcid.org/0000-0001-7747-1204
Daniel Clemente GaruloUnidad de Reumatología, Hospital del Niño Jesus, Madrid, Spain.
Virginia PascualDepartment of Pediatrics, Drukier Institute for Children's Health, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0002-8806-8426
Tess LevySeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eric J MallackDivision of Child Neurology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY, USA.ORCID http://orcid.org/0000-0002-2678-8807
Daniel G CalameDivision of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Timothy LotzeDivision of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
James R LupskiTexas Children's Hospital, Houston, TX, USA.ORCID http://orcid.org/0000-0001-9907-9246
Huihua DingChina Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Tomalika R UllahCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Giles D WaltersDepartment of Renal Medicine, The Canberra Hospital, Canberra, Australian Capital Territory, Australia.
Mark E KoinaDepartment of Anatomical Pathology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia.
Matthew C CookCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Nan ShenChina Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University, Shanghai, China.ORCID http://orcid.org/0000-0002-5875-4417
Carmen de Lucas CollantesSección de Nefrología, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Ben CorryResearch School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0002-6324-442X
Michael P GantierShanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai, Jiao Tong University (SJTUSM), Shanghai, China.ORCID http://orcid.org/0000-0003-3740-698X
Vicki AthanasopoulosCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0002-5764-5948
Carola G VinuesaCentre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia. carola.vinuesa@crick.ac.uk.ORCID http://orcid.org/0000-0001-9799-0298
Australian National University · AUHospital Infantil Universitario Niño Jesús · ESBaylor College of Medicine · USSouth Australia Pathology · AUCanberra Hospital · AURenji Hospital · CNShanghai Jiao Tong University · CNCincinnati Children's Hospital Medical Center · USCornell University · USHudson Institute of Medical Research · AUIcahn School of Medicine at Mount Sinai · USNewYork–Presbyterian Hospital · USWalter and Eliza Hall Institute of Medical Research · AU
Funding
Baylor-Johns Hopkins Center for Mendelian GeneticsU54HG006542 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2012 to 2015
$15.6MBaylor-Johns Hopkins Center for Mendelian GeneticsUM1HG006542 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2016 to 2020
$14.5MFrequency of variants of unknown significance by ancestry groups in the All of Us Research Program cohortU01HG011758 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI RICHARD A GIBBS, JAMES R. LUPSKI · 2021 to 2026
$13.8MSTRUCTURAL VARIATION IN NEUROLOGICAL DISEASER35NS105078 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI LUPSKI, JAMES R. · 2018 to 2025
$6.0MNHGRI NIH HHS U01 HG011758NHGRI NIH HHS U54 HG006542NHGRI NIH HHS UM1 HG006542NINDS NIH HHS R35 NS105078
Abstract
Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of human systemic autoimmune disease
Indexed as
Gain of Function MutationLupus Erythematosus, SystemicToll-Like Receptor 7AnimalsAutoimmunityB-LymphocytesCyclic GMPGuanosineHumansMiceMyeloid Differentiation Factor 88Cyclic GMPGuanosineMYD88 protein, humanMyeloid Differentiation Factor 88TLR7 protein, humanToll-Like Receptor 7
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.